UniProt P54311
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (P54311)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (UniProt P54311): 151 experimental structures and 1 predicted model on GenesisL1, 545 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P54311
- Protein
- Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
- Experimental structures
- 151
- Predicted models
- 1
- Pockets
- 545 · 79 records with a druggable one
Structures
152 records of P54311 in the MolNFT archive: 151 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3SN6 | Crystal structure of the beta2 adrenergic receptor-Gs protein complex | x-ray diffraction | B | — | — |
| 3SN6 | Crystal structure of the BETA2 adrenergic receptor-gs protein complex | x-ray diffraction | B | — | — |
| 5TDH | The crystal structure of the dominant negative mutant G protein ALPHA(I)-1-beta-1-gamma-2… | x-ray diffraction | B, J | — | — |
| 5VAI | Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein | electron microscopy | B | — | 7 (best 0.84) |
| 5VAI | Cryo-EM structure of the activated glucagon-like peptide-1 receptor in complex with G protein | electron microscopy | B | — | — |
| 6CMO | Rhodopsin-Gi complex | electron microscopy | B | — | 7 (best 0.83) |
| 6CMO | Rhodopsin-gi complex | electron microscopy | B | — | — |
| 6LPB | Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein | electron microscopy | B | — | — |
| 6LPB | Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein | electron microscopy | B | — | — |
| 6NBF | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid… | electron microscopy | B | — | — |
| 6NBF | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid… | electron microscopy | B | — | — |
| 6NBH | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid… | electron microscopy | B | — | — |
| 6NBI | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid… | electron microscopy | B | — | 7 (best 0.85) |
| 6NBI | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid… | electron microscopy | B | — | — |
| 6WWZ | Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a go protein | electron microscopy | B | — | — |
| 7BW0 | Active human TGR5 complex with a synthetic agonist 23H | electron microscopy | B | — | — |
| 7CZ5 | Cryo-EM structure of the human growth hormone-releasing hormone receptor-Gs protein complex | electron microscopy | B | — | 7 (best 0.81) |
| 7CZ5 | Cryo-EM structure of the human growth hormone-releasing hormone receptor-gs protein complex | electron microscopy | B | — | — |
| 7D3S | Human SECR in complex with an engineered Gs heterotrimer | electron microscopy | B | — | 5 (best 0.81) |
| 7D3S | Human secr in complex with an engineered gs heterotrimer | electron microscopy | B | — | — |
| 7DH5 | Dog beta3 adrenergic receptor bound to mirabegron in complex with a miniGs heterotrimer | electron microscopy | B | — | 4 (best 0.84) |
| 7DH5 | Dog BETA3 adrenergic receptor bound to mirabegron in complex with a minigs heterotrimer | electron microscopy | B | — | — |
| 7DTY | Structural basis of ligand selectivity conferred by the human glucose-dependent insulinotropic… | electron microscopy | B | — | 8 (best 0.83) |
| 7DTY | Structural basis of ligand selectivity conferred by the human glucose- dependent insulinotropic… | electron microscopy | B | — | — |
| 7DUQ | Cryo-EM structure of the compound 2 and glp-1-bound human glp-1 receptor-gs complex | electron microscopy | B | — | — |
| 7DUR | Cryo-EM structure of the compound 2-bound human glp-1 receptor-gs complex | electron microscopy | B | — | — |
| 7DW9 | Cryo-EM structure of human V2 vasopressin receptor in complex with an gs protein | electron microscopy | B | — | — |
| 7EIB | Cryo-EM structure of the type 1 bradykinin receptor in complex with the des-ARG10-kallidin and an… | electron microscopy | C | — | — |
| 7EQ1 | GPR114-gs-SCFV16 complex | electron microscopy | B | — | — |
| 7EVM | Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex | electron microscopy | B | — | — |
| 7EVM | Cryo-EM structure of the compound 2-bound human glp-1 receptor-gs complex | electron microscopy | B | — | — |
| 7F16 | Cryo-EM structure of parathyroid hormone receptor type 2 in complex with a tuberoinfundibular… | electron microscopy | B | — | 8 (best 0.83) |
| 7F16 | Cryo-EM structure of parathyroid hormone receptor type 2 in complex with a tuberoinfundibular… | electron microscopy | B | — | — |
| 7F2O | Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an Gq protein | electron microscopy | B | — | 7 (best 0.81) |
| 7F2O | Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an gq protein | electron microscopy | B | — | — |
| 7FIG | luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs complex | electron microscopy | B | — | 5 (best 0.82) |
| 7FIG | Luteinizing HORMONE/CHORIOGONADOTROPIN RECEPTOR(S277I)-chorionic gonadotropin-gs complex | electron microscopy | B | — | — |
| 7FIH | luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553 complex | electron microscopy | B | — | 5 (best 0.81) |
| 7FIH | Luteinizing HORMONE/CHORIOGONADOTROPIN RECEPTOR(S277I)-chorionic gonadotropin-gs-ORG43553 complex | electron microscopy | B | — | — |
| 7FII | luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-Gs complex | electron microscopy | B | — | 8 (best 0.84) |
| 7FII | Luteinizing HORMONE/CHORIOGONADOTROPIN receptor-chorionic gonadotropin-gs complex | electron microscopy | B | — | — |
| 7FIM | Cryo-EM structure of the tirzepatide (LY3298176)-bound human GLP-1R-Gs complex | electron microscopy | B | — | 9 (best 0.79) |
| 7FIM | Cryo-EM structure of the tirzepatide (LY3298176)-bound human glp-1R-gs complex | electron microscopy | B | — | — |
| 7FIN | Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GIPR-Gs complex | electron microscopy | B | — | 7 (best 0.83) |
| 7FIN | Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human gipr-gs complex | electron microscopy | B | — | — |
| 7FIY | Cryo-EM structure of the tirzepatide-bound human GIPR-Gs complex | electron microscopy | B | — | — |
| 7FIY | Cryo-EM structure of the tirzepatide-bound human gipr-gs complex | electron microscopy | B | — | — |
| 7LJC | Allosteric modulator LY3154207 binding to skf-81297-bound dopamine receptor 1 in complex with… | electron microscopy | B | — | — |
| 7LJD | Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs… | electron microscopy | B | — | 7 (best 0.84) |
| 7LJD | Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with minigs… | electron microscopy | B | — | — |
| 7MBX | Human Cholecystokinin 1 receptor (CCK1R) Gs complex | electron microscopy | B | — | 7 (best 0.82) |
| 7MBX | Human cholecystokinin 1 receptor (CCK1R) gs complex | electron microscopy | B | — | — |
| 7MBY | Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex | electron microscopy | B | — | 5 (best 0.82) |
| 7MBY | Human cholecystokinin 1 receptor (CCK1R) gq chimera (mgsqi) complex | electron microscopy | B | — | — |
| 7PIU | Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R)… | electron microscopy | B | — | 5 (best 0.81) |
| 7PIU | Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R)… | electron microscopy | B | — | — |
| 7PIV | Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A… | electron microscopy | B | — | 5 (best 0.81) |
| 7PIV | Active melanocortin-4 receptor (MC4R)- gs protein complex bound to agonist ndp-alpha-msh at 2.86 a… | electron microscopy | B | — | — |
| 7T6S | Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1… | electron microscopy | B | — | — |
| 7T6T | Structure of the human FPR1-Gi complex with fMLFII | electron microscopy | B | — | 4 (best 0.82) |
92 records more on the page itself.
Experiment against prediction
- 7MBX chain B against the predicted model P54311: TM-score 1.00, RMSD 0.39 Å
- 7MBX chain B against the predicted model P54311: TM-score 1.00, RMSD 0.39 Å
- 7X8R chain B against the predicted model P54311: TM-score 1.00, RMSD 0.41 Å
- 7X8R chain B against the predicted model P54311: TM-score 1.00, RMSD 0.41 Å
- 7VVL chain B against the predicted model P54311: TM-score 1.00, RMSD 0.40 Å
- 7VVL chain B against the predicted model P54311: TM-score 1.00, RMSD 0.40 Å
- 7Y36 chain B against the predicted model P54311: TM-score 1.00, RMSD 0.41 Å
- 7PIU chain B against the predicted model P54311: TM-score 1.00, RMSD 0.42 Å
- 7PIU chain B against the predicted model P54311: TM-score 1.00, RMSD 0.42 Å
- 7YU5 chain B against the predicted model P54311: TM-score 1.00, RMSD 0.43 Å
Elsewhere
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