Dog BETA3 adrenergic receptor bound to mirabegron in complex with a minigs heterotrimer

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• H6U · 2-(2-azanyl-1,3-thiazol-4-yl)-N-[4-[2-[[(2R)-2-oxidanyl-2-phenyl-ethyl]amino]ethyl]phenyl]ethanamide · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7DH5 · Dog beta3 adrenergic receptor bound to mirabegron in complex with a miniGs heterotrimer · the same entry in another collection · chain R against R, TM-score 1.00
• P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
• O02662 · AlphaFold monomer V2.0 prediction for beta-3 adrenergic receptor (O02662) · a predicted model of the same protein · chain R against A, TM-score 0.91
• P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.65

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P63092
• Every structure of UniProt P54311
• Every structure of UniProt P63212
• Every structure of UniProt O02662
• Elsewhere: RCSB PDB 7DH5 · PDBe 7DH5 · UniProt P63092 · UniProt P54311 · UniProt P63212 · UniProt O02662