UniProt P63092
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (UniProt P63092): 155 experimental structures on GenesisL1, 8 ligands bound, 179 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P63092
- Protein
- Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
- Experimental structures
- 155
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 179 · 24 records with a druggable one
Structures
155 records of P63092 in the MolNFT archive: 155 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5G53 | Structure of the adenosine A2A receptor bound to an engineered G protein | x-ray diffraction | C, D | — | — |
| 5UZ7 | Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs… | electron microscopy | A | — | — |
| 5VAI | Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein | electron microscopy | A | — | 12 (best 0.84) |
| 5VAI | Cryo-EM structure of the activated glucagon-like peptide-1 receptor in complex with G protein | electron microscopy | A | — | — |
| 6AU6 | Crystal structure of GDP-bound human gnas R201C mutant | x-ray diffraction | A | GDP, MG, CL | — |
| 6B3J | 3.3 ångström phase-plate cryo-EM structure of a biased agonist-bound human glp-1 receptor-gs complex | electron microscopy | A | — | — |
| 6E3Y | Cryo-EM structure of the active, gs-protein complexed, human cgrp receptor | electron microscopy | A | — | — |
| 6E67 | Structure of BETA2 adrenergic receptor fused to a gs peptide | x-ray diffraction | A, B | P0G | — |
| 6EG8 | Structure of the GDP-bound gs heterotrimer | x-ray diffraction | I, J, K, L | GDP, MG | — |
| 6GDG | Cryo-EM structure of the adenosine A2A receptor bound to a minigs heterotrimer | electron microscopy | D | — | — |
| 6LI3 | Cryo-EM structure of GPR52-minigs-NB35 | electron microscopy | A | — | — |
| 6LMK | Cryo-EM structure of the human glucagon receptor in complex with gs | electron microscopy | A | — | — |
| 6NI3 | B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex | electron microscopy | A | — | — |
| 6NI3 | B2V2R-gs protein subcomplex of a GPCR-G protein-beta-arrestin mega- complex | electron microscopy | A | — | — |
| 6NIY | A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs… | electron microscopy | A | — | — |
| 6ORV | Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor | electron microscopy | AP | — | 10 (best 0.81) |
| 6P9X | CRF1 receptor gs GPCR protein complex with CRF1 peptide | electron microscopy | A | — | — |
| 6P9Y | PAC1 GPCR receptor complex | electron microscopy | A | — | — |
| 6PB0 | Cryo-EM structure of urocortin 1-bound corticotropin-releasing factor 1 receptor in complex with gs… | electron microscopy | A | — | — |
| 6PB1 | Cryo-EM structure of urocortin 1-bound corticotropin-releasing factor 2 receptor in complex with gs… | electron microscopy | A | — | — |
| 6UUN | Cryoem structure of the active adrenomedullin 1 receptor G protein complex with adrenomedullin… | electron microscopy | A | — | — |
| 6UUS | Cryoem structure of the active adrenomedullin 2 receptor G protein complex with adrenomedullin… | electron microscopy | A | — | — |
| 6UVA | Cryoem structure of the active adrenomedullin 2 receptor G protein complex with adrenomedullin 2… | electron microscopy | A | — | — |
| 6VCB | Cryo-EM structure of the glucagon-like peptide-1 receptor in complex with G protein, glp-1 peptide… | electron microscopy | A | — | — |
| 6VN7 | Cryo-EM structure of an activated VIP1 receptor-G protein complex | electron microscopy | A | — | — |
| 6WHC | Cryoem structure of the glucagon receptor with a dual-agonist peptide | electron microscopy | A | — | — |
| 6WI9 | Human secretin receptor gs complex | electron microscopy | A | — | — |
| 6WPW | GCGR-Gs signaling complex bound to a designed glucagon derivative | electron microscopy | C | — | — |
| 6WPW | Gcgr-gs signaling complex bound to a designed glucagon derivative | electron microscopy | C | — | — |
| 6WZG | Human secretin receptor gs complex | electron microscopy | A | — | — |
| 6X18 | Glp-1 peptide hormone bound to glucagon-like peptide-1 (glp-1) receptor | electron microscopy | A | — | — |
| 6X19 | Non peptide agonist chu-128, bound to glucagon-like peptide-1 (glp-1) receptor | electron microscopy | A | — | — |
| 6X1A | Non peptide agonist pf-06882961, bound to glucagon-like peptide-1 (glp-1) receptor | electron microscopy | A | — | — |
| 7AUE | Melanocortin receptor 4 (MC4R) gs protein complex | electron microscopy | A | — | — |
| 7BB6 | Avp-V2R-galphas-BETA1-GAMMA2-NB35 (L state) | electron microscopy | E | — | — |
| 7BB7 | Avp-V2R-galphas-BETA1-GAMMA2-NB35(T state) | electron microscopy | E | — | — |
| 7BPH | Crystal structure of gppnhp-bound gnas in complex with the cyclic peptide inhibitor GN13 | x-ray diffraction | A | GNP, MG, CL | — |
| 7BW0 | Active human TGR5 complex with a synthetic agonist 23H | electron microscopy | A | — | — |
| 7BZ2 | Cryo-EM structure of the formoterol-bound BETA2 adrenergic receptor-gs protein complex. | electron microscopy | A | — | — |
| 7CFM | Cryo-EM structure of the P395-bound gpbar-gs complex | electron microscopy | A | — | — |
| 7CFN | Cryo-EM structure of the int-777-bound gpbar-gs complex | electron microscopy | A | — | — |
| 7CKW | Cryo-EM structure of fenoldopam bound dopamine receptor DRD1-gs signaling complex | electron microscopy | A | — | — |
| 7CKX | Cryo-EM structure of A77636 bound dopamine receptor DRD1-gs signaling complex | electron microscopy | A | — | — |
| 7CKY | Cryo-EM structure of PW0464 bound dopamine receptor DRD1-gs signaling complex | electron microscopy | A | — | — |
| 7CKZ | Cryo-EM structure of dopamine and LY3154207 bound dopamine receptor DRD1-gs signaling complex | — | — | — | |
| 7CRH | Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-Gs signaling complex | electron microscopy | A | — | 7 (best 0.85) |
| 7CRH | Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-gs signaling complex | electron microscopy | A | — | — |
| 7CX2 | Cryo-EM structure of the PGE2-bound EP2-Gs complex | electron microscopy | A | — | 5 (best 0.84) |
| 7CX2 | Cryo-EM structure of the PGE2-bound EP2-gs complex | electron microscopy | A | — | — |
| 7CX3 | Cryo-EM structure of the taprenepag-bound EP2-gs complex | electron microscopy | A | — | — |
| 7CX4 | Cryo-EM structure of the evatanepag-bound EP2-gs complex | electron microscopy | A | — | — |
| 7CZ5 | Cryo-EM structure of the human growth hormone-releasing hormone receptor-gs protein complex | electron microscopy | A | PLM | — |
| 7D3S | Human secr in complex with an engineered gs heterotrimer | electron microscopy | A | — | — |
| 7D7M | Cryo-EM structure of the prostaglandin E receptor EP4 coupled to G protein | electron microscopy | D | — | — |
| 7DH5 | Dog beta3 adrenergic receptor bound to mirabegron in complex with a miniGs heterotrimer | electron microscopy | A | — | 6 (best 0.84) |
| 7DH5 | Dog BETA3 adrenergic receptor bound to mirabegron in complex with a minigs heterotrimer | electron microscopy | A | — | — |
| 7DHI | Cryo-EM structure of the partial agonist salbutamol-bound BETA2 adrenergic receptor-gs protein… | electron microscopy | A | — | — |
| 7DHR | Cryo-EM structure of the full agonist isoprenaline-bound BETA2 adrenergic receptor-gs protein… | electron microscopy | A | — | — |
| 7DUQ | Cryo-EM structure of the compound 2 and glp-1-bound human glp-1 receptor-gs complex | electron microscopy | A | — | — |
| 7DUR | Cryo-EM structure of the compound 2-bound human glp-1 receptor-gs complex | electron microscopy | A | — | — |
95 records more on the page itself.
Ligands
- GDP · Guanosine-5'-diphosphate · in 5 records
- GTP · Guanosine-5'-triphosphate · in 4 records
- MG · Magnesium ion · in 4 records
- CL · Chloride ion · in 3 records
- PLM · Palmitic acid · in 2 records
- ACE · Acetyl group · in 1 record
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 1 record
- P0G · 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl) ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one · in 1 record
Experiment against prediction
- 5G53 chain D against the predicted model Q5JWF2: TM-score 0.93, RMSD 1.54 Å
- 5G53 chain C against the predicted model Q5JWF2: TM-score 0.91, RMSD 1.75 Å
- 8THK chain A against the predicted model P50148: TM-score 0.82, RMSD 2.66 Å
- 7MBY chain A against the predicted model P63096: TM-score 0.78, RMSD 3.16 Å
- 8THK chain A against the predicted model P04899: TM-score 0.78, RMSD 3.14 Å
- 8J9N chain C against the predicted model P50148: TM-score 0.78, RMSD 2.87 Å
- 7RA3 chain A against the predicted model P08754: TM-score 0.75, RMSD 3.19 Å
- 8IOD chain A against the predicted model P63096: TM-score 0.74, RMSD 3.35 Å
- 7EZK chain A against the predicted model P63096: TM-score 0.74, RMSD 3.15 Å
- 6PB1 chain A against the predicted model P63096: TM-score 0.74, RMSD 3.40 Å
Elsewhere
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