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Ligand · GNP

GNP · Phosphoaminophosphonic acid-guanylate ester

GNP, Phosphoaminophosphonic acid-guanylate ester (C10 H17 N6 O13 P3, 522.2 g/mol), in the MolNFT structures on GenesisL1: bound in 358 records (280 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most…

Component
GNP
Formula
C10 H17 N6 O13 P3
Class
ligand
Structures
358
PDB entries
280

Binding sites

GNP in 358 structures; the first of them:

  • 4XVQ · H-Ras Y137E · GNP A202 · binds ALA11, GLY12, GLY13, VAL14, GLY15, LYS16, SER17, ALA18 and 17 more
  • 4Z51 · High Resolution Human Septin 3 GTPase domain · GNP A401 · binds GLN69, SER70, GLY71, LEU72, GLY73, LYS74, SER75, THR76 and 13 more
  • 4ZI3 · BART-like domain of BARTL1/CCDC104 aa1-133 in complex with Arl3FL bound to GppNHp in P1… · GNP A301 · binds LEU25, ASP26, ASN27, ALA28, GLY29, LYS30, THR31, THR32 and 15 more
  • 5DE3 · The Crystal structure of Chlamydomonas reinhardtii Arl3 bound to GppNHp · GNP A201 · binds LEU24, ASP25, ASN26, ALA27, GLY28, LYS29, THR30, THR31 and 15 more
  • 5DH9 · Crystal Structure of PKI NES Flip Mutant Peptide in complex with CRM1-Ran-RanBP1 · GNP A301 · binds ASP18, GLY19, GLY20, THR21, GLY22, LYS23, THR24, THR25 and 19 more
  • 5DIF · Crystal Structure of CPEB4 NES Peptide in complex with CRM1-Ran-RanBP1 · GNP A301 · binds ASP18, GLY19, GLY20, THR21, GLY22, LYS23, THR24, THR25 and 19 more
  • 5EE9 · Complex structure of OSYCHF1 with GMP-PNP · GNP A401 · binds PRO33, ASN34, VAL35, GLY36, LYS37, SER38, THR39, ALA96 and 4 more
  • 5FPH · The GTPase domains of the immunity-related Irga6 dimerize in a parallel head-to-head… · GNP A501 · binds GLU77, THR78, GLY79, SER80, GLY81, LYS82, SER83, SER84 and 9 more
  • 5GAD · RNC-SRP-SR complex early state · GNP i1400 · binds LEU108, GLN109, GLY110, ALA111, GLY112, LYS113, THR114, THR115 and 17 more
  • 5GAF · RNC in complex with SRP · GNP i1400 · binds LEU108, GLN109, GLY110, ALA111, GLY112, LYS113, THR114, THR115 and 11 more
  • 5IQD · Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex… · GNP A500 · binds ILE208, SER214, ALA216, ILE224, LYS226, TYR237, TYR274, GLU276 and 6 more
  • 5IQE · Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex… · GNP A500 · binds ILE208, GLY211, SER214, ALA216, ILE224, LYS226, TYR237, TYR274 and 7 more
  • 5IQH · Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) S214A mutant… · GNP A500 · binds ILE208, ALA214, ALA216, ILE224, LYS226, TYR274, GLU276, ILE277 and 5 more
  • 5IQI · Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) Y237F mutant… · GNP A500 · binds ILE208, GLY211, SER214, ALA216, ILE224, LYS226, PHE237, TYR274 and 7 more
  • 5IZM · The crystal structure of human eEFSec in complex with GDPNP · GNP A1002 · binds ILE16, ASP17, SER18, GLY19, LYS20, THR21, ALA22, ILE47 and 12 more
  • 5JBH · Cryo-EM structure of a full archaeal ribosomal translation initiation complex in the P-IN… · GNP 7502 · binds VAL18, ASP19, HIS20, GLY21, LYS22, THR23, THR24, TRP33 and 13 more
  • 5JLJ · Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1 · GNP A301 · binds ASP18, GLY19, GLY20, THR21, GLY22, LYS23, THR24, THR25 and 17 more
  • 5L3Q · Structure of the GTPase heterodimer of human SRP54 and SRalpha · GNP A502 · binds LEU109, GLN110, GLY111, SER112, GLY113, LYS114, THR115, THR116 and 16 more

Residues it binds most

GLY 701, LYS 726, ALA 618, ASP 715, SER 700, THR 608, VAL 573, ASN 600, PHE 581, LEU 569 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • GOL · Glycerol
  • ZN · Zinc ion
  • NA · Sodium ion
  • CL · Chloride ion
  • FMT · Formic acid
  • GDP · Guanosine-5'-diphosphate
  • SO4 · Sulfate ion
  • CA · Calcium ion
  • PO4 · Phosphate ion
  • EDO · 1,2-ethanediol
  • PGE · Triethylene glycol

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