UniProt P63212

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (P63212)

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (UniProt P63212): 264 experimental structures and 1 predicted model on GenesisL1, 292 pockets. Binding sites, druggability and experiment against prediction…

UniProt: P63212
Protein: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Experimental structures: 264
Predicted models: 1
Pockets: 292 · 109 records with a druggable one

Structures

265 records of P63212 in the MolNFT archive: 264 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1GG2	G protein heterotrimer mutant GI_ALPHA_1(G203A) BETA_1 GAMMA_2 with GDP bound	x-ray diffraction	G	—	—
1GG2	G protein heterotrimer mutant GI_ALPHA_1(G203A) BETA_1 GAMMA_2 with GDP bound	x-ray diffraction	G	—	—
1GP2	G protein heterotrimer GI_ALPHA_1 BETA_1 GAMMA_2 with GDP bound	x-ray diffraction	G	—	—
1GP2	G protein heterotrimer GI_ALPHA_1 BETA_1 GAMMA_2 with GDP bound	x-ray diffraction	G	—	—
1OMW	Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G…	x-ray diffraction	G	—	—
1OMW	Crystal structure of the complex between G protein-coupled receptor kinase 2 and heterotrimeric G…	x-ray diffraction	G	—	—
1XHM	The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma…	x-ray diffraction	B	—	—
1XHM	The crystal structure of a biologically active peptide (sigk) bound to a G protein BETA:GAMMA…	x-ray diffraction	B	—	—
2BCJ	Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma…	x-ray diffraction	G	—	—
2BCJ	Crystal structure of G protein-coupled receptor kinase 2 in complex with galpha-Q and gbetagamma…	x-ray diffraction	G	—	—
3AH8	Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890	x-ray diffraction	G	—	—
3AH8	Structure of heterotrimeric G protein galpha-Q beta gamma in complex with an inhibitor ym-254890	x-ray diffraction	G	—	—
3CIK	Human GRK2 in Complex with Gbetagamma subunits	x-ray diffraction	G	—	—
3CIK	Human GRK2 in complex with gbetagamma subunits	x-ray diffraction	G	—	—
3KRW	Human GRK2 in complex with Gbetgamma subunits and balanol (soak)	x-ray diffraction	G	—	—
3KRW	Human GRK2 in complex with gbetgamma subunits and balanol (soak)	x-ray diffraction	G	—	—
3KRX	Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal)	x-ray diffraction	G	—	—
3KRX	Human GRK2 in complex with gbetgamma subunits and balanol (co-crystal)	x-ray diffraction	G	—	—
3PSC	Bovine GRK2 in complex with Gbetagamma subunits	x-ray diffraction	G	—	—
3PSC	Bovine GRK2 in complex with gbetagamma subunits	x-ray diffraction	G	—	—
3PVU	Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)	x-ray diffraction	G	—	—
3PVU	Bovine GRK2 in complex with gbetagamma subunits and a selective kinase inhibitor (CMPD101)	x-ray diffraction	G	—	—
3PVW	Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A)	x-ray diffraction	G	—	—
3PVW	Bovine GRK2 in complex with gbetagamma subunits and a selective kinase inhibitor (CMPD103A)	x-ray diffraction	G	—	—
3SN6	Crystal structure of the beta2 adrenergic receptor-Gs protein complex	x-ray diffraction	G	—	—
3SN6	Crystal structure of the BETA2 adrenergic receptor-gs protein complex	x-ray diffraction	G	—	—
3UZS	Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric…	x-ray diffraction	G	—	—
3UZS	Structure of the C13.28 RNA aptamer bound to the G protein-coupled receptor kinase 2-heterotrimeric…	x-ray diffraction	G	—	—
3V5W	Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine	x-ray diffraction	G	—	—
3V5W	Human G protein-coupled receptor kinase 2 in complex with soluble gbetagamma subunits and paroxetine	x-ray diffraction	G	—	—
4MK0	Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed…	x-ray diffraction	G	—	—
4MK0	Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed…	x-ray diffraction	G	—	—
4PNK	G protein-coupled receptor kinase 2 in complex with GSK180736A	x-ray diffraction	G	—	—
4PNK	G protein-coupled receptor kinase 2 in complex with GSK180736A	x-ray diffraction	G	—	—
5TDH	The crystal structure of the dominant negative mutant G protein ALPHA(I)-1-beta-1-gamma-2…	x-ray diffraction	G, K	—	—
5VAI	Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein	electron microscopy	G	—	3 (best 0.84)
5VAI	Cryo-EM structure of the activated glucagon-like peptide-1 receptor in complex with G protein	electron microscopy	G	—	—
5WG3	Human GRK2 in complex with Gbetagamma subunits and CCG258748	x-ray diffraction	G	—	2 (best 0.45)
5WG3	Human GRK2 in complex with gbetagamma subunits and CCG258748	x-ray diffraction	G	—	—
5WG4	Human GRK2 in complex with Gbetagamma subunits and CCG257284	x-ray diffraction	G	—	—
5WG4	Human GRK2 in complex with gbetagamma subunits and CCG257284	x-ray diffraction	G	—	—
5WG5	Human GRK2 in complex with Gbetagamma subunits and CCG224061	x-ray diffraction	G	—	2 (best 0.46)
5WG5	Human GRK2 in complex with gbetagamma subunits and CCG224061	x-ray diffraction	G	—	—
6C2Y	Human GRK2 in complex with Gbetagamma subunits and CCG257142	x-ray diffraction	G	—	—
6C2Y	Human GRK2 in complex with gbetagamma subunits and CCG257142	x-ray diffraction	G	—	—
6CMO	Rhodopsin-Gi complex	electron microscopy	G	—	2 (best 0.72)
6CMO	Rhodopsin-gi complex	electron microscopy	G	—	—
6LPB	Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein	electron microscopy	G	—	—
6LPB	Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein	electron microscopy	G	—	—
6NBF	Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid…	electron microscopy	G	—	—
6NBF	Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid…	electron microscopy	G	—	—
6NBH	Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid…	electron microscopy	G	—	3 (best 0.75)
6NBH	Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid…	electron microscopy	G	—	—
6NBI	Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid…	electron microscopy	G	—	3 (best 0.85)
6NBI	Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid…	electron microscopy	G	—	—
6PCV	Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac…	electron microscopy	G	—	—
6PCV	Single particle reconstruction of phosphatidylinositol (3,4,5) trisphosphate-dependent rac…	electron microscopy	G	—	—
6U7C	Human GRK2 in complex with Gbetagamma subunits and CCG258747	x-ray diffraction	G	—	1 (best 0.44)
6U7C	Human GRK2 in complex with gbetagamma subunits and CCG258747	x-ray diffraction	G	—	—
7BW0	Active human TGR5 complex with a synthetic agonist 23H	electron microscopy	G	—	2 (best 0.74)

205 records more on the page itself.

Experiment against prediction

1XHM chain B against the predicted model P63212: TM-score 0.74, RMSD 1.41 Å
1XHM chain B against the predicted model P63212: TM-score 0.74, RMSD 1.41 Å
7EVM chain G against the predicted model P63212: TM-score 0.74, RMSD 1.62 Å
7EVM chain G against the predicted model P63212: TM-score 0.74, RMSD 1.62 Å
7V9L chain Y against the predicted model P63212: TM-score 0.73, RMSD 1.77 Å
7V9L chain Y against the predicted model P63212: TM-score 0.73, RMSD 1.77 Å
7DUR chain G against the predicted model P63212: TM-score 0.72, RMSD 1.67 Å
7DUR chain G against the predicted model P63212: TM-score 0.72, RMSD 1.67 Å
7TD1 chain G against the predicted model P63212: TM-score 0.72, RMSD 2.10 Å
7TD1 chain G against the predicted model P63212: TM-score 0.72, RMSD 2.10 Å

Elsewhere

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