MolNFT v1 · #189311 · protein
Cryo-EM structure of the SV1-gs complex.
7V9L · Guanine nucleotide-binding protein G(S) subunit alpha…: “Cryo-EM structure of the SV1-gs complex.”. Electron microscopy, 10 pockets (best druggability 0.80). MolNFT v1 #189311 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7V9L
- Type
- protein
- Length
- 1,019 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Ghrh receptor…
- UniProt
- Q9HB45, P63212, P54311
- Pockets
- 10 · best druggability 0.80
Structure
electron microscopy · 5 distinct chains · 38% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 237 | 49% helix, 17% strand | — |
| R | Ghrh receptor splice variant 1,GHRH receptor splice variant 1,GHRH receptor splice variant 1,SV1 | protein | 257 | 82% helix, 0% strand | Q9HB45 |
| Y | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 58 | 60% helix, 0% strand | P63212 |
| N | Nanobody 35 | protein | 126 | 5% helix, 43% strand | — |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 341 | 8% helix, 46% strand | P54311 |
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 577 | 0.80 | 0.86 | 57 | empty |
| 2 | 1041 | 0.76 | 0.78 | 60 | empty |
| 3 | 821 | 0.75 | 0.79 | 65 | empty |
| 4 | 610 | 0.72 | 0.80 | 66 | empty |
| 5 | 486 | 0.71 | 0.81 | 33 | empty |
Interfaces
6 interfaces between chains.
- Y–B · 2349 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 1573 Ų buried · 30 hydrogen bonds · protein-protein
- A–R · 1110 Ų buried · 13 hydrogen bonds · protein-protein
- A–N · 714 Ų buried · 6 hydrogen bonds · protein-protein
- N–B · 571 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7V9L · Cryo-EM structure of the SV1-Gs complex. · the same entry in another collection · chain R against R, TM-score 1.00
- P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain Y against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HB45
- Every structure of UniProt P63212
- Every structure of UniProt P54311
- Elsewhere: RCSB PDB 7V9L · PDBe 7V9L · UniProt Q9HB45 · UniProt P63212 · UniProt P54311
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.