MolNFT v1 · #177840 · protein
Cryo-EM structure of the compound 2-bound human glp-1 receptor-gs complex
7EVM: “Cryo-EM structure of the compound 2-bound human glp-1 receptor-gs complex”. Electron microscopy, 2 ligands (CLR, HNO). MolNFT v1 #177840 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EVM
- Type
- protein
- Length
- 1,037 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P63092, P54311, P63212, P43220
- Ligands
- CLR, HNO
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 235 | — | P63092 |
| B | — | protein | 338 | — | P54311 |
| G | — | protein | 56 | — | P63212 |
| N | — | protein | 126 | — | — |
| R | — | protein | 282 | — | P43220 |
Ligands and binding sites
- CLR · Cholesterol · ligand · 6 copies · chains R
- HNO · N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7EVM · Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex · the same entry in another collection · chain R against R, TM-score 1.00
- P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain R against A, TM-score 0.97
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P54311
- Every structure of UniProt P63212
- Every structure of UniProt P43220
- Elsewhere: RCSB PDB 7EVM · PDBe 7EVM · UniProt P63092 · UniProt P54311 · UniProt P63212 · UniProt P43220
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