UniProt P43220
Glucagon-like peptide 1 receptor (P43220)
Glucagon-like peptide 1 receptor (UniProt P43220), EC 3.2.1.17: 73 experimental structures and 1 predicted model on GenesisL1, 26 ligands bound, 100 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P43220
- Protein
- Glucagon-like peptide 1 receptor
- EC
- 3.2.1.17
- Experimental structures
- 73
- Predicted models
- 1
- Ligands
- 26
- Pockets
- 100 · 14 records with a druggable one
Structures
74 records of P43220 in the MolNFT archive: 73 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3C59 | Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain | x-ray diffraction | A | — | — |
| 3C59 | Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain | x-ray diffraction | A | — | — |
| 3C5T | Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain | x-ray diffraction | A | — | — |
| 3C5T | Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain | x-ray diffraction | A | — | — |
| 3IOL | Crystal structure of Glucagon-Like Peptide-1 in complex with the extracellular domain of the… | x-ray diffraction | A | — | — |
| 3IOL | Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the… | x-ray diffraction | A | — | — |
| 4ZGM | Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular… | x-ray diffraction | A | 32M | — |
| 4ZGM | Crystal structure of semaglutide peptide backbone in complex with the glp-1 receptor extracellular… | x-ray diffraction | A | — | — |
| 5E94 | Antibody-bound Glucagon-like Peptide-1 receptor extracellular domain | x-ray diffraction | G, H | — | 4 (best 0.37) |
| 5E94 | Antibody-bound glucagon-like peptide-1 receptor extracellular domain | x-ray diffraction | G, H | — | — |
| 5NX2 | Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide… | x-ray diffraction | A | NAG, SOG | 3 (best 0.82) |
| 5NX2 | Crystal structure of thermostabilised full-length glp-1R in complex with a truncated peptide… | x-ray diffraction | A | 9DK, 9DQ, 9DT, 9DW, 9DZ, NAG | — |
| 5OTT | Extracellular domain of GLP-1 receptor in complex with exendin-4 variant Gly2Hcs/Thr5Hcs | x-ray diffraction | A | — | — |
| 5OTT | Extracellular domain of glp-1 receptor in complex with exendin-4 variant GLY2HCS/THR5HCS | x-ray diffraction | A | — | — |
| 5OTU | Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Hcs/Thr11Hcs | x-ray diffraction | A, C | — | 1 (best 0.67) |
| 5OTU | Extracellular domain of glp-1 receptor in complex with glp-1 variant ALA8HCS/THR11HCS | x-ray diffraction | A, C | — | — |
| 5OTV | Extracellular domain of glp-1 receptor in complex with glp-1 variant ALA8CYC/THR11HCS | x-ray diffraction | C, A | — | — |
| 5OTW | Extracellular domain of glp-1 receptor in complex with glp-1 variant ALA8HCS/THR11CYS | x-ray diffraction | C, A | — | — |
| 5OTX | Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cys/Thr11Cys | x-ray diffraction | A, C | — | 4 (best 0.48) |
| 5OTX | Extracellular domain of glp-1 receptor in complex with glp-1 variant ALA8CYS/THR11CYS | x-ray diffraction | A, C | — | — |
| 5VEW | Structure of the human GLP-1 receptor complex with PF-06372222 | x-ray diffraction | A, B | 97Y, OLA | 13 (best 0.69) |
| 5VEW | Structure of the human glp-1 receptor complex with pf-06372222 | x-ray diffraction | A, B | 97Y, OLA | — |
| 5VEX | Structure of the human GLP-1 receptor complex with NNC0640 | x-ray diffraction | A, B | 97V | 14 (best 0.70) |
| 5VEX | Structure of the human glp-1 receptor complex with NNC0640 | x-ray diffraction | A, B | 97V | — |
| 6B3J | 3.3 ångström phase-plate cryo-EM structure of a biased agonist-bound human glp-1 receptor-gs complex | electron microscopy | R | — | — |
| 6GB1 | Crystal structure of the GLP1 receptor ECD with Peptide 11 | x-ray diffraction | A | SO4 | — |
| 6GB1 | Crystal structure of the GLP1 receptor ecd with peptide 11 | x-ray diffraction | A | NH2, SO4 | — |
| 6KJV | Structure of thermal-STABILISED(M9) human glp-1 receptor transmembrane domain | x-ray diffraction | A, B | 97Y | — |
| 6KK1 | Structure of thermal-stabilised(M8) human GLP-1 receptor transmembrane domain | x-ray diffraction | A, B | 97Y | — |
| 6KK1 | Structure of thermal-STABILISED(M8) human glp-1 receptor transmembrane domain | x-ray diffraction | A, B | 97Y | — |
| 6KK7 | Structure of thermal-STABILISED(M6) human glp-1 receptor transmembrane domain | x-ray diffraction | A, B | 97Y | — |
| 6LN2 | Crystal structure of full length human GLP1 receptor in complex with Fab fragment (FAB7F38) | x-ray diffraction | A | NAG, ZN, 97Y | — |
| 6ORV | Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor | electron microscopy | RP | N2V | 6 (best 0.76) |
| 6VCB | Cryo-EM structure of the glucagon-like peptide-1 receptor in complex with G protein, glp-1 peptide… | electron microscopy | R | QW7 | — |
| 6X18 | Glp-1 peptide hormone bound to glucagon-like peptide-1 (glp-1) receptor | electron microscopy | R | — | — |
| 6X19 | Non peptide agonist chu-128, bound to glucagon-like peptide-1 (glp-1) receptor | electron microscopy | R | UK1 | — |
| 6X1A | Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 (GLP-1) Receptor | electron microscopy | R | UK4 | 6 (best 0.85) |
| 6X1A | Non peptide agonist pf-06882961, bound to glucagon-like peptide-1 (glp-1) receptor | electron microscopy | R | UK4 | — |
| 6XOX | cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970 | electron microscopy | R | V6G | 6 (best 0.79) |
| 6XOX | Cryo-EM of human glp-1R bound to non-peptide agonist LY3502970 | electron microscopy | R | V6G | — |
| 7C2E | Glp-1R-gs complex structure with a small molecule full agonist | electron microscopy | R | FFR | — |
| 7DUQ | Cryo-EM structure of the compound 2 and glp-1-bound human glp-1 receptor-gs complex | electron microscopy | R | HNO, CLR | — |
| 7DUR | Cryo-EM structure of the compound 2-bound human glp-1 receptor-gs complex | electron microscopy | R | HNO, CLR | — |
| 7E14 | Compound2_GLP-1R_OWL833_Gs complex structure | electron microscopy | R | V6G, CLR, HNO | — |
| 7E14 | COMPOUND2_GLP-1R_OWL833_GS complex structure | electron microscopy | R | V6G, CLR, HNO | — |
| 7EVM | Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex | electron microscopy | R | HNO, CLR | — |
| 7EVM | Cryo-EM structure of the compound 2-bound human glp-1 receptor-gs complex | electron microscopy | R | HNO, CLR | — |
| 7FIM | Cryo-EM structure of the tirzepatide (LY3298176)-bound human glp-1R-gs complex | electron microscopy | R | — | — |
| 7KI0 | Semaglutide-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs protein | electron microscopy | R | — | — |
| 7KI1 | Taspoglutide-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs protein | electron microscopy | R | — | — |
| 7LCI | PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex | electron microscopy | R | UK4 | — |
| 7LCI | Pf 06882961 bound to the glucagon-like peptide-1 receptor (glp-1R):GS complex | electron microscopy | R | UK4 | — |
| 7LCJ | PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex | electron microscopy | R | UK4 | 3 (best 0.85) |
| 7LCJ | Pf 06882961 bound to the glucagon-like peptide-1 receptor (glp-1R):GS complex | electron microscopy | R | UK4 | — |
| 7LCK | Pf 06882961 bound to the glucagon-like peptide-1 receptor (glp-1R) | electron microscopy | R | UK4 | — |
| 7LLL | Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein | electron microscopy | R | — | 9 (best 0.74) |
| 7LLL | Exendin-4-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs protein | electron microscopy | R | — | — |
| 7LLY | Oxyntomodulin-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs protein | electron microscopy | R | — | — |
| 7RG9 | Cryo-EM of human glucagon-like peptide 1 receptor glp-1R in apo form | electron microscopy | R | — | — |
| 7RGP | Cryo-EM of human glucagon-like peptide 1 receptor glp-1R bound to tirzepatide | electron microscopy | R | — | — |
14 records more on the page itself.
Ligands
- 97Y · N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine · in 7 records
- UK4 · 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid · in 7 records
- CLR · Cholesterol · in 6 records
- HNO · N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine · in 6 records
- V6G · 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
- 97V · 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl) phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl) benzamide · in 2 records
- D6M · N-hexadecanoyl-L-glutamic acid · in 2 records
- OLA · Oleic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- SOG · octyl 1-thio-beta-D-glucopyranoside · in 2 records
- WB2 · 2,4-bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1, 3-bis[[4-(2-methylpropanoylamino) phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid · in 2 records
- 32M · 3,6,9,12,15,18-hexaoxahexacosan-1-ol · in 1 record
- 82L · 2-[(4-{6-[(2,4-difluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5-yl)methyl]-1H-benzimidazole-6-carboxylic acid · in 1 record
- 9DK · 3-[2-(1~{H}-imidazol-4-yl)ethylamino]-2,2-dimethyl-3-oxidanylidene-propanoic acid · in 1 record
- 9DQ · (2~{S})-2-azanyl-3-(1~{H}-1,2,3,4-tetrazol-5-yl) propanoic acid · in 1 record
- 9DT · (2~{S})-2-azanyl-3-(2-fluorophenyl)-2-methyl-propanoic acid · in 1 record
- 9DW · (2~{S})-2-azanyl-3-[4-(2-ethyl-4-methoxy-phenyl) phenyl]propanoic acid · in 1 record
- 9DZ · (2~{S})-2-azanyl-5-(3,5-dimethylphenyl)pentanamide · in 1 record
- BYI · 2,4-bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1, 3-bis[[4-[(2-methylpropan-2-yl) oxycarbonylamino]phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid · in 1 record
- FFR · 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid · in 1 record
- N2V · N-{(3S,8S)-3-{4-[(3,4-dichlorophenyl)methoxy]phenyl}-7-[(1S)-1-phenylpropyl]-2,3,6,7,8,9-hexahydro[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl}-4-(2,3-dimethylpyridin-4-yl)-L-phenylalanine · in 1 record
- NH2 · Amino group · in 1 record
- QW7 · 1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole · in 1 record
- UK1 · 3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4H)-one · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 5OTU chain C against the predicted model P43220: TM-score 0.98, RMSD 0.53 Å
- 5OTV chain C against the predicted model P43220: TM-score 0.98, RMSD 0.53 Å
- 5OTW chain C against the predicted model P43220: TM-score 0.98, RMSD 0.56 Å
- 4ZGM chain A against the predicted model P43220: TM-score 0.98, RMSD 0.59 Å
- 4ZGM chain A against the predicted model P43220: TM-score 0.98, RMSD 0.59 Å
- 5OTX chain A against the predicted model P43220: TM-score 0.98, RMSD 0.59 Å
- 5OTX chain A against the predicted model P43220: TM-score 0.98, RMSD 0.59 Å
- 3IOL chain A against the predicted model P43220: TM-score 0.98, RMSD 0.61 Å
- 3IOL chain A against the predicted model P43220: TM-score 0.98, RMSD 0.61 Å
- 5OTT chain A against the predicted model P43220: TM-score 0.97, RMSD 0.84 Å
Elsewhere
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