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Ligand · FFR

FFR · 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid

FFR, 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid (C30 H27 F N6 O4, 554.6 g/mol), in the MolNFT structures on…

Component
FFR
Formula
C30 H27 F N6 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

FFR in 2 structures; the first of them:

  • 7C2E · GLP-1R-Gs complex structure with a small molecule full agonist · FFR R501 · binds LEU32, TRP33, VAL36, GLN37, GLU138, LEU141, LYS197, LEU201 and 12 more
  • 7C2E · Glp-1R-gs complex structure with a small molecule full agonist · FFR R501 · binds LEU32, TRP33, VAL36, GLN37, LEU141, LYS197, LEU201, MET204 and 8 more

Residues it binds most

LEU 2, PHE 2, CYS 2, ARG 2, ASP 2, GLN 2, LYS 2, MET 2, THR 2, TRP 2 (residue and the binding sites it lines).

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