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Ligand · UK1

UK1 · 3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4H)-one

UK1, 3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol…

Component
UK1
Formula
C47 H49 F2 N11 O5
Class
ligand
Structures
2
PDB entries
1

Binding sites

UK1 in 2 structures; the first of them:

  • 6X19 · Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor · UK1 R501 · binds SER31, TRP33, GLU34, PRO137, GLU138, LEU141, LEU144, TYR145 and 17 more
  • 6X19 · Non peptide agonist chu-128, bound to glucagon-like peptide-1 (glp-1) receptor · UK1 R501 · binds SER31, TRP33, GLU34, PRO137, GLU138, LEU141, LEU144, TYR145 and 14 more

Residues it binds most

LEU 2, TYR 2, GLU 2, LYS 2, MET 2, ASN 2, ASP 2, CYS 2, PHE 2, PRO 2 (residue and the binding sites it lines).

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