V6G · 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one

Binding sites

V6G in 4 structures; the first of them:

• 6XOX · cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970 · V6G R501 · binds SER31, TRP33, GLU34, PRO137, GLU138, LEU141, LEU144, TYR145 and 16 more
• 7E14 · Compound2_GLP-1R_OWL833_Gs complex structure · V6G R501 · binds SER31, GLU34, PRO137, GLU138, LEU141, LEU144, TYR145, TYR148 and 15 more
• 6XOX · Cryo-EM of human glp-1R bound to non-peptide agonist LY3502970 · V6G R501 · binds SER31, TRP33, GLU34, PRO137, GLU138, LEU141, LEU144, TYR145 and 11 more
• 7E14 · COMPOUND2_GLP-1R_OWL833_GS complex structure · V6G R501 · binds SER31, GLU34, PRO137, GLU138, LEU141, LEU144, TYR145, TYR148 and 15 more

Residues it binds most

LEU 4, TYR 4, GLU 4, LYS 4, MET 4, CYS 4, PHE 4, PRO 4, SER 4, ALA 3 (residue and the binding sites it lines).

Found with

• CLR · Cholesterol
• HNO · N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine