MolNFT v1 · #75507 · protein

Bovine GRK2 in complex with gbetagamma subunits

3PSC · Beta-adrenergic receptor kinase 1: “Bovine GRK2 in complex with gbetagamma subunits”. X-ray diffraction, 13 pockets (best druggability 0.77). MolNFT v1 #75507 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3PSC
Type: protein
Length: 1,014 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-adrenergic receptor kinase 1; Guanine nucleotide-binding protein G(I)/G(S)/G(T)…
EC: 2.7.11.15
UniProt: P21146, P62871, P63212
Pockets: 13 · best druggability 0.77

Structure

x-ray diffraction · 3 distinct chains · 34% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)	protein	614	46% helix, 16% strand	P21146
B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	protein	339	7% helix, 47% strand	P62871
G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	protein	61	57% helix, 0% strand	P63212

Pockets

13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	564	0.77	0.84	49	empty
2	269	0.61	0.80	37	empty
3	390	0.58	0.75	36	empty
4	65	0.55	0.88	17	empty
5	238	0.52	0.76	33	empty

Interfaces

2 interfaces between chains.

B–G · 2238 Å² buried · 22 hydrogen bonds · protein-protein
A–B · 1134 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (nonstandard).

Compared structures

3PSC · Bovine GRK2 in complex with Gbetagamma subunits · the same entry in another collection · chain A against A, TM-score 1.00
P62871 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
P21146 · AlphaFold monomer V2.0 prediction for beta-adrenergic receptor kinase 1 (P21146) · a predicted model of the same protein · chain A against A, TM-score 0.99
P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.63

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21146
Every structure of UniProt P62871
Every structure of UniProt P63212
Elsewhere: RCSB PDB 3PSC · PDBe 3PSC · UniProt P21146 · UniProt P62871 · UniProt P63212

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