UniProt P21146
Beta-adrenergic receptor kinase 1 (P21146)
Beta-adrenergic receptor kinase 1 (UniProt P21146), EC 2.7.11.15: 24 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P21146
- Protein
- Beta-adrenergic receptor kinase 1
- EC
- 2.7.11.15
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 25 · 3 records with a druggable one
Structures
25 records of P21146 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OMW | Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G… | x-ray diffraction | A | — | — |
| 1OMW | Crystal structure of the complex between G protein-coupled receptor kinase 2 and heterotrimeric G… | x-ray diffraction | A | — | — |
| 1YM7 | G Protein-Coupled Receptor Kinase 2 (GRK2) | x-ray diffraction | A, B, C, D | — | — |
| 1YM7 | G protein-coupled receptor kinase 2 (GRK2) | x-ray diffraction | A, B, C, D | — | — |
| 2BCJ | Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma… | x-ray diffraction | A | — | — |
| 2BCJ | Crystal structure of G protein-coupled receptor kinase 2 in complex with galpha-Q and gbetagamma… | x-ray diffraction | A | — | — |
| 3PSC | Bovine GRK2 in complex with Gbetagamma subunits | x-ray diffraction | A | — | — |
| 3PSC | Bovine GRK2 in complex with gbetagamma subunits | x-ray diffraction | A | — | — |
| 3PVU | Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101) | x-ray diffraction | A | — | — |
| 3PVU | Bovine GRK2 in complex with gbetagamma subunits and a selective kinase inhibitor (CMPD101) | x-ray diffraction | A | — | — |
| 3PVW | Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A) | x-ray diffraction | A | — | — |
| 3PVW | Bovine GRK2 in complex with gbetagamma subunits and a selective kinase inhibitor (CMPD103A) | x-ray diffraction | A | — | — |
| 3UZS | Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric… | x-ray diffraction | A | — | — |
| 3UZS | Structure of the C13.28 RNA aptamer bound to the G protein-coupled receptor kinase 2-heterotrimeric… | x-ray diffraction | A | — | — |
| 3UZT | Structure of the C13.18 RNA Aptamer in Complex with G Protein-Coupled Receptor Kinase 2 | x-ray diffraction | A | — | — |
| 3UZT | Structure of the C13.18 RNA aptamer in complex with G protein-coupled receptor kinase 2 | x-ray diffraction | A | — | — |
| 5HE0 | Bovine GRK2 in complex with Gbetagamma subunits and CCG215022 | x-ray diffraction | A | 453 | — |
| 5HE0 | Bovine GRK2 in complex with gbetagamma subunits and CCG215022 | x-ray diffraction | A | — | — |
| 5HE2 | Bovine GRK2 in complex with Gbetagamma subunits and CCG224406 | x-ray diffraction | A | F0S | 8 (best 0.79) |
| 5HE2 | Bovine GRK2 in complex with gbetagamma subunits and CCG224406 | x-ray diffraction | A | — | — |
| 5HE3 | Bovine GRK2 in complex with gbetagamma subunits and CCG224411 | x-ray diffraction | A | — | — |
| 5UKM | bovine GRK2 in complex with human Gbetagamma subunits and CCG258208 (14as) | x-ray diffraction | A | T0E, MG | 9 (best 0.80) |
| 5UKM | Bovine GRK2 in complex with human gbetagamma subunits and CCG258208 (14AS) | x-ray diffraction | A | T0E, MG | — |
| 8JPC | cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2 | electron microscopy | G | SRW, STU | 8 (best 0.81) |
| P21146 | AlphaFold monomer V2.0 prediction for beta-adrenergic receptor kinase 1 (P21146) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 2 records
- T0E · 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl) oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(1H-pyrazol-5-yl)methyl]benzamide · in 2 records
- 453 · (4S)-4-{4-fluoro-3-[(pyridin-2-ylmethyl)carbamoyl]phenyl}-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide · in 1 record
- F0S · (4~{S})-4-[3-[(2,6-dimethoxyphenyl)methylcarbamoyl]-4-fluoranyl-phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide · in 1 record
- SRW · 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol · in 1 record
- STU · Staurosporine · in 1 record
Experiment against prediction
- 2BCJ chain A against the predicted model P21146: TM-score 0.99, RMSD 0.83 Å
- 2BCJ chain A against the predicted model P21146: TM-score 0.99, RMSD 0.83 Å
- 5HE3 chain A against the predicted model P21146: TM-score 0.99, RMSD 0.81 Å
- 5HE2 chain A against the predicted model P21146: TM-score 0.99, RMSD 0.92 Å
- 5HE2 chain A against the predicted model P21146: TM-score 0.99, RMSD 0.92 Å
- 5HE0 chain A against the predicted model P21146: TM-score 0.99, RMSD 0.93 Å
- 5HE0 chain A against the predicted model P21146: TM-score 0.99, RMSD 0.93 Å
- 1YM7 chain A against the predicted model P21146: TM-score 0.99, RMSD 0.95 Å
- 1YM7 chain A against the predicted model P21146: TM-score 0.99, RMSD 0.95 Å
- 3PVU chain A against the predicted model P21146: TM-score 0.99, RMSD 1.02 Å
Elsewhere
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