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Ligand · SRW

SRW · 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol

SRW, 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol (C26 H31 F N4 O2, 450.6 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (3 PDB entries). Every binding site…

Component
SRW
Formula
C26 H31 F N4 O2
Class
ligand
Structures
3
PDB entries
3

Binding sites

SRW in 3 structures; the first of them:

  • 8FN0 · CryoEM structure of Go-coupled NTSR1 with a biased allosteric modulator · SRW A501 · binds VAL102, LEU106, VAL160, LEU163, SER164, ARG167, ILE171, ASN257 and 13 more
  • 8JPC · cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2 · SRW R501 · binds LEU105, LEU108, VAL159, LEU162, SER163, ARG166, ILE170, ASN256 and 13 more
  • 8JPF · Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes · SRW R501 · binds LEU105, LEU108, VAL159, LEU162, SER163, ARG166, ILE170, ASN256 and 9 more

Residues it binds most

LEU 3, VAL 3, ASN 3, ILE 3, SER 3, ARG 3, TYR 3, GLY 1, PHE 2, CYS 1 (residue and the binding sites it lines).

Found with

  • ALF · Tetrafluoroaluminate ion
  • GDP · Guanosine-5'-diphosphate
  • STU · Staurosporine
  • MG · Magnesium ion

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