Human GRK2 in complex with gbetagamma subunits and CCG257284

Structure

x-ray diffraction · 3 distinct chains.

Ligands and binding sites

• AFV · 2-fluoro-5-[(3S,4R)-3-{[(1H-indazol-5-yl) oxy]methyl}piperidin-4-yl]-N-[(pyridin-2-yl) methyl]benzamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5WG4 · Human GRK2 in complex with Gbetagamma subunits and CCG257284 · the same entry in another collection · chain A against A, TM-score 1.00
• P62871 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
• P25098 · AlphaFold monomer V2.0 prediction for beta-adrenergic receptor kinase 1 (P25098) · a predicted model of the same protein · chain A against A, TM-score 0.98
• P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.67

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P25098
• Every structure of UniProt P62871
• Every structure of UniProt P63212
• Elsewhere: RCSB PDB 5WG4 · PDBe 5WG4 · UniProt P25098 · UniProt P62871 · UniProt P63212