UniProt O02662

Beta-3 adrenergic receptor (O02662)

Beta-3 adrenergic receptor (UniProt O02662): 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 34 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: O02662
Protein: Beta-3 adrenergic receptor
Experimental structures: 6
Predicted models: 1
Ligands: 3
Pockets: 34 · 6 records with a druggable one

Structures

7 records of O02662 in the MolNFT archive: 6 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
7DH5	Dog beta3 adrenergic receptor bound to mirabegron in complex with a miniGs heterotrimer	electron microscopy	R	H6U	4 (best 0.76)
7DH5	Dog BETA3 adrenergic receptor bound to mirabegron in complex with a minigs heterotrimer	electron microscopy	R	H6U	4 (best 0.76)
7XJH	Isoproterenol-activated dog beta3 adrenergic receptor	electron microscopy	R	5FW	6 (best 0.77)
7XJH	Isoproterenol-activated dog BETA3 adrenergic receptor	electron microscopy	R	5FW	6 (best 0.77)
7XJI	Solabegron-activated dog beta3 adrenergic receptor	electron microscopy	R	EI5	7 (best 0.76)
7XJI	Solabegron-activated dog BETA3 adrenergic receptor	electron microscopy	R	EI5	7 (best 0.76)
O02662	AlphaFold monomer V2.0 prediction for beta-3 adrenergic receptor (O02662)	predicted	A	—	—

Ligands

5FW · Isoprenaline · in 2 records
EI5 · 3-[3-[2-[[(2~{S})-2-(3-chlorophenyl)-2-oxidanyl-ethyl]amino]ethylamino]phenyl]benzoic acid · in 2 records
H6U · 2-(2-azanyl-1,3-thiazol-4-yl)-N-[4-[2-[[(2R)-2-oxidanyl-2-phenyl-ethyl]amino]ethyl]phenyl]ethanamide · in 2 records

Experiment against prediction

7XJH chain R against the predicted model O02662: TM-score 0.92, RMSD 2.10 Å
7XJH chain R against the predicted model O02662: TM-score 0.92, RMSD 2.10 Å
7XJI chain R against the predicted model O02662: TM-score 0.92, RMSD 2.12 Å
7XJI chain R against the predicted model O02662: TM-score 0.92, RMSD 2.12 Å
7DH5 chain R against the predicted model O02662: TM-score 0.91, RMSD 2.22 Å
7DH5 chain R against the predicted model O02662: TM-score 0.91, RMSD 2.22 Å

Elsewhere

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