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Ligand · 5FW

5FW · Isoprenaline

5FW, Isoprenaline (C11 H17 N O3, 211.3 g/mol), in the MolNFT structures on GenesisL1: bound in 11 records (7 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
5FW
Formula
C11 H17 N O3
Class
ligand
Structures
11
PDB entries
7

Binding sites

5FW in 11 structures; the first of them:

  • 5YTU · Structure of human SOD1 complexed with isoproteranol in C2221 space group · 5FW A201 · binds ASP11, GLY12, PRO13
  • 6H7J · ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY Nb80 · 5FW A401 · binds TRP117, THR118, ASP121, VAL122, VAL125, PHE201, SER211, SER212 and 6 more
  • 7JJO · Structural Basis of the Activation of Heterotrimeric Gs-protein by Isoproterenol-bound… · 5FW R401 · binds TRP117, THR118, ASP121, VAL122, VAL125, PHE201, SER211, SER212 and 6 more
  • 7S0F · Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi protein · 5FW R401 · binds TRP117, THR118, ASP121, VAL122, VAL125, THR126, PHE201, SER211 and 7 more
  • 5YTU · Structure of human SOD1 complexed with isoproteranol in C2221 space group · 5FW A201 · binds ASP11, GLY12, PRO13
  • 6H7J · Activated turkey BETA1 adrenoceptor with bound agonist isoprenaline and nanobody NB80 · 5FW A401 · binds TRP117, THR118, ASP121, VAL122, VAL125, PHE201, SER211, SER212 and 6 more
  • 7DHR · Cryo-EM structure of the full agonist isoprenaline-bound BETA2 adrenergic receptor-gs… · 5FW R601 · binds ASP113, VAL117, PHE193, SER203, SER207, PHE290, ASN293, ASN312
  • 7JJO · Structural basis of the activation of heterotrimeric gs-protein by isoproterenol-bound… · 5FW R401 · binds TRP117, THR118, ASP121, VAL122, PHE201, SER211, SER215, PHE306 and 3 more
  • 7S0F · Isoproterenol bound BETA1 adrenergic receptor in complex with heterotrimeric gi protein · 5FW R401 · binds TRP117, ASP121, VAL125, PHE201, SER211, SER215, PHE306, PHE307 and 3 more
  • 7S0G · Isoproterenol bound BETA1 adrenergic receptor in complex with heterotrimeric GI/S chimera… · 5FW R401 · binds TRP117, ASP121, VAL122, PHE201, SER211, PHE306, ASN310, ASN329 and 1 more
  • 7XJH · Isoproterenol-activated dog BETA3 adrenergic receptor · 5FW R401 · binds TRP113, THR114, ASP117, VAL121, PHE198, SER208, SER209, SER212 and 4 more

Residues it binds most

PHE 11, SER 11, ASN 11, VAL 11, ASP 13, TRP 10, TYR 10, THR 8, GLY 2, PRO 2 (residue and the binding sites it lines).

Found with

  • 2CV · Hega-10
  • S4P · Dihydrogen tetrasulfide
  • TAM · Tris(hydroxyethyl)aminomethane
  • NA · Sodium ion
  • ZN · Zinc ion
  • GOL · Glycerol

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