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Ligand · 2CV

2CV · Hega-10

2CV, Hega-10 (C18 H37 N O7, 379.5 g/mol), in the MolNFT structures on GenesisL1: bound in 27 records (18 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
2CV
Formula
C18 H37 N O7
Class
ligand
Structures
27
PDB entries
18

Binding sites

2CV in 27 structures; the first of them:

  • 5HVD · Full length Open-form Sodium Channel NavMs I218C · 2CV A304 · binds MET189, PRO193, ASN194, TRP196, ILE200, MET204
  • 5HVX · Full length Wild-Type Open-form Sodium Channel NavMs · 2CV A304 · binds MET189, PRO193, ASN194, TRP196, ILE200, MET204
  • 6CSB · V308E mutant of cytochrome P450 2D6 complexed with thioridazine · 2CV A604 · binds PHE120, SER304, ALA305, THR309, VAL370, GLY373, VAL374, PHE483 and 1 more
  • 6H7J · ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY Nb80 · 2CV A403 · binds LEU171, TRP181, ASN204, ALA206, TYR207, ALA210, ILE214, VAL60 and 6 more
  • 6H7M · ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST SALBUTAMOL AND NANOBODY… · 2CV A501 · binds LEU171, PRO176, TRP181, ASN204, ALA206, TYR207, ALA210, VAL60 and 4 more
  • 6H7O · ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND WEAK PARTIAL AGONIST CYANOPINDOLOL AND… · 2CV A403 · binds LEU171, PRO176, TRP181, ASN204, ALA206, TYR207, ALA210, ILE214 and 7 more
  • 6SX5 · Full length Mutant Open-form Sodium Channel NavMs · 2CV A304 · binds ARG186, MET189, PRO193, ASN194, TRP196, ILE200, MET204
  • 6SXE · Crystal Structure of the Voltage-Gated Sodium Channel NavMs (F208L) in complex with… · 2CV A304 · binds MET189, PRO193, ASN194, TRP196, ILE200
  • 6SXF · Crystal Structure of the Voltage-Gated Sodium Channel NavMs (F208L) in complex with… · 2CV A304 · binds ARG186, MET189, PRO193, ASN194, TRP196, ILE200
  • 6YZ0 · Full length Open-form Sodium Channel NavMs F208L in complex with Cannabidiol (CBD) · 2CV A304 · binds ARG186, MET189, PRO193, TRP196, ILE200, MET204
  • 6Z8C · Crystal Structure of the Voltage-Gated Sodium Channel NavMs (F208L) in complex with… · 2CV A304 · binds ARG186, MET189, PRO193, ASN194, TRP196, ILE200
  • 6CSB · V308E mutant of cytochrome P450 2D6 complexed with thioridazine · 2CV A604 · binds PHE120, SER304, ALA305, THR309, VAL370, GLY373, VAL374, PHE483 and 1 more
  • 6H7J · Activated turkey BETA1 adrenoceptor with bound agonist isoprenaline and nanobody NB80 · 2CV A403 · binds LEU171, TRP181, ASN204, ALA206, TYR207, ALA210, ILE214, VAL60 and 6 more

Residues it binds most

ILE 59, LEU 59, THR 48, VAL 45, TRP 49, ALA 22, ARG 32, MET 33, LYS 29, GLY 21 (residue and the binding sites it lines).

Found with

  • NA · Sodium ion
  • 12P · Dodecaethylene glycol
  • 5FW · Isoprenaline
  • 68H · Salbutamol
  • 7PG · 2,5,8,11,14,17,20,23-octaoxapentacosan-25-ol
  • 9XY · Endoxifen
  • CD0 · 2-[(1R,2R,5S)-5-methyl-2-(prop-1-en-2-yl)cyclohexyl]-5-pentylbenzene-1,3-diol
  • CTX · (Z)-2-[4-(1,2)-diphenyl-1-butenyl)-phenoxy]-N,N-dimethylethanamine
  • HEM · Protoporphyrin IX containing Fe
  • OHT · 4-hydroxytamoxifen
  • P32 · 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile
  • QBN · 2-[4-[(~{Z})-1,2-diphenylbut-1-enyl]phenoxy]-~{N}-methyl-ethanamine

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