Cryo-EM structure of the BOC5-bound hglp-1R-gs complex

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• BYI · 2,4-bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1, 3-bis[[4-[(2-methylpropan-2-yl) oxycarbonylamino]phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7X8R · Cryo-EM structure of the Boc5-bound hGLP-1R-Gs complex · the same entry in another collection · chain G against G, TM-score 1.00
• P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.96
• P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain R against A, TM-score 0.91

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P63092
• Every structure of UniProt P54311
• Every structure of UniProt P59768
• Every structure of UniProt P43220
• Elsewhere: RCSB PDB 7X8R · PDBe 7X8R · UniProt P63092 · UniProt P54311 · UniProt P59768 · UniProt P43220