UniProt P59768
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (P59768)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (UniProt P59768): 493 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 354 pockets. Binding sites, druggability and experiment against…
- UniProt
- P59768
- Protein
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
- Experimental structures
- 493
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 354 · 118 records with a druggable one
Structures
494 records of P59768 in the MolNFT archive: 493 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4KFM | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with… | x-ray diffraction | G | — | — |
| 4KFM | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (KIR3.2) in complex with… | x-ray diffraction | G | — | — |
| 5HE0 | Bovine GRK2 in complex with Gbetagamma subunits and CCG215022 | x-ray diffraction | G | — | — |
| 5HE0 | Bovine GRK2 in complex with gbetagamma subunits and CCG215022 | x-ray diffraction | G | — | — |
| 5HE1 | Human GRK2 in complex with Gbetagamma subunits and CCG224062 | x-ray diffraction | G | — | — |
| 5HE1 | Human GRK2 in complex with gbetagamma subunits and CCG224062 | x-ray diffraction | G | — | — |
| 5HE2 | Bovine GRK2 in complex with gbetagamma subunits and CCG224406 | x-ray diffraction | G | — | — |
| 5HE3 | Bovine GRK2 in complex with gbetagamma subunits and CCG224411 | x-ray diffraction | G | — | — |
| 5UKK | Human GRK2 in complex with human G-beta-gamma subunits and CCG211998 (14ak) | x-ray diffraction | G | — | — |
| 5UKK | Human GRK2 in complex with human G-beta-gamma subunits and CCG211998 (14AK) | x-ray diffraction | G | — | — |
| 5UKL | Human GRK2 in complex with gbetagamma subunits and CCG222886 (14BD) | x-ray diffraction | G | — | — |
| 5UKM | Bovine GRK2 in complex with human gbetagamma subunits and CCG258208 (14AS) | x-ray diffraction | G | — | — |
| 5UZ7 | Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs… | electron microscopy | G | — | — |
| 6B3J | 3.3 ångström phase-plate cryo-EM structure of a biased agonist-bound human glp-1 receptor-gs complex | electron microscopy | G | — | — |
| 6CRK | Heterotrimeric G-protein in complex with an antibody fragment | x-ray diffraction | G | — | — |
| 6D9H | Cryo-EM structure of the human adenosine A1 receptor-GI2-protein complex bound to its endogenous… | electron microscopy | G | — | — |
| 6DDE | Mu opioid receptor-gi protein complex | electron microscopy | C | — | — |
| 6DDF | Mu Opioid Receptor-Gi Protein Complex | electron microscopy | C | — | 1 (best 0.51) |
| 6DDF | Mu opioid receptor-gi protein complex | electron microscopy | C | — | — |
| 6E3Y | Cryo-EM structure of the active, gs-protein complexed, human cgrp receptor | electron microscopy | G | — | — |
| 6EG8 | Structure of the GDP-bound gs heterotrimer | x-ray diffraction | C, E, G, H | — | — |
| 6G79 | Coupling specificity of heterotrimeric go to the serotonin 5-HT1B receptor | electron microscopy | G | — | — |
| 6GDG | Cryo-EM structure of the adenosine A2A receptor bound to a minigs heterotrimer | electron microscopy | C | — | — |
| 6K41 | Cryo-EM structure of ALPHA2BAR-goa complex | electron microscopy | G | — | — |
| 6K42 | cryo-EM structure of alpha2BAR-Gi1 complex | electron microscopy | G | — | 1 (best 0.55) |
| 6K42 | Cryo-EM structure of ALPHA2BAR-GI1 complex | electron microscopy | G | — | — |
| 6KPF | Cryo-EM structure of a class A GPCR with G protein complex | electron microscopy | C | — | — |
| 6KPF | Cryo-EM structure of a class a GPCR with G protein complex | electron microscopy | C | — | — |
| 6KPG | Cryo-EM structure of CB1-G protein complex | electron microscopy | C | — | — |
| 6KPG | Cryo-EM structure of CB1-G protein complex | electron microscopy | C | — | — |
| 6LFM | Cryo-EM structure of a class a GPCR | electron microscopy | C | — | — |
| 6LFO | Cryo-EM structure of a class A GPCR monomer | electron microscopy | C | — | — |
| 6LFO | Cryo-EM structure of a class a GPCR monomer | electron microscopy | C | — | — |
| 6LI3 | Cryo-EM structure of GPR52-minigs-NB35 | electron microscopy | G | — | — |
| 6LMK | Cryo-EM structure of the human glucagon receptor in complex with gs | electron microscopy | C | — | — |
| 6LML | Cryo-EM structure of the human glucagon receptor in complex with GI1 | electron microscopy | C | — | — |
| 6M1H | Cryoem structure of human PAC1 receptor in complex with maxadilan | electron microscopy | D | — | — |
| 6M1I | CryoEM structure of human PAC1 receptor in complex with PACAP38 | electron microscopy | D | — | — |
| 6M1I | Cryoem structure of human PAC1 receptor in complex with PACAP38 | electron microscopy | D | — | — |
| 6M8S | Crystal structure of the KCTD12 H1 domain in complex with GBETA1GAMMA2 subunits | x-ray diffraction | I, J, L, E, F | — | — |
| 6N4B | Cannabinoid receptor 1-G protein complex | electron microscopy | C | — | — |
| 6NI3 | B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex | electron microscopy | G | — | — |
| 6NI3 | B2V2R-gs protein subcomplex of a GPCR-G protein-beta-arrestin mega- complex | electron microscopy | G | — | — |
| 6NIY | A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs… | electron microscopy | G | — | — |
| 6OIJ | Muscarinic acetylcholine receptor 1-G11 protein complex | electron microscopy | G | — | 2 (best 0.51) |
| 6OIJ | Muscarinic acetylcholine receptor 1-G11 protein complex | electron microscopy | G | — | — |
| 6OIK | Muscarinic acetylcholine receptor 2-go complex | electron microscopy | G | — | — |
| 6OMM | Cryo-EM structure of formyl peptide receptor 2/LIPOXIN A4 receptor in complex with gi | electron microscopy | C | — | — |
| 6ORV | Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor | electron microscopy | GP | — | 3 (best 0.81) |
| 6OS9 | human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) | electron microscopy | C | — | 1 (best 0.48) |
| 6OS9 | Human neurotensin receptor 1 (HNTSR1) - GI1 protein complex in canonical conformation (C state) | electron microscopy | C | — | — |
| 6OSA | Human neurotensin receptor 1 (HNTSR1) - GI1 protein complex in non- canonical conformation (nc… | electron microscopy | C | — | — |
| 6OT0 | Structure of human Smoothened-Gi complex | electron microscopy | G | — | — |
| 6OT0 | Structure of human smoothened-gi complex | electron microscopy | G | — | — |
| 6P9X | CRF1 Receptor Gs GPCR protein complex with CRF1 peptide | electron microscopy | G | — | 2 (best 0.75) |
| 6P9X | CRF1 receptor gs GPCR protein complex with CRF1 peptide | electron microscopy | G | — | — |
| 6P9Y | PAC1 GPCR Receptor complex | electron microscopy | G | — | 2 (best 0.81) |
| 6P9Y | PAC1 GPCR receptor complex | electron microscopy | G | — | — |
| 6PB0 | Cryo-EM structure of urocortin 1-bound corticotropin-releasing factor 1 receptor in complex with gs… | electron microscopy | G | — | — |
| 6PB1 | Cryo-EM structure of urocortin 1-bound corticotropin-releasing factor 2 receptor in complex with gs… | electron microscopy | G | — | — |
434 records more on the page itself.
Ligands
- GER · Geran-8-yl geran · in 1 record
Experiment against prediction
- 7P02 chain G against the predicted model P59768: TM-score 0.97, RMSD 0.39 Å
- 7W56 chain G against the predicted model P59768: TM-score 0.97, RMSD 0.46 Å
- 7VL9 chain G against the predicted model P59768: TM-score 0.97, RMSD 0.45 Å
- 7WZ7 chain E against the predicted model P59768: TM-score 0.97, RMSD 0.45 Å
- 8XQN chain C against the predicted model P59768: TM-score 0.97, RMSD 0.47 Å
- 8YN6 chain C against the predicted model P59768: TM-score 0.97, RMSD 0.46 Å
- 8KFX chain C against the predicted model P59768: TM-score 0.97, RMSD 0.47 Å
- 8G05 chain G against the predicted model P59768: TM-score 0.97, RMSD 0.47 Å
- 7VUH chain G against the predicted model P59768: TM-score 0.97, RMSD 0.47 Å
- 8WWI chain C against the predicted model P59768: TM-score 0.96, RMSD 0.49 Å
Elsewhere
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