MolNFT v1 · #178042 · protein
Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an gq protein
7F2O · G subunit Q (GI1-gq chimeric): “Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an gq protein”. Electron microscopy, 10 pockets (best druggability 0.81). MolNFT v1 #178042 on GenesisL1: 3D…
- PDB
- 7F2O
- Type
- protein
- Length
- 1,150 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G subunit Q (GI1-gq chimeric); Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit…
- UniProt
- P54311, P30411, P63212
- Pockets
- 10 · best druggability 0.81
Structure
electron microscopy · 6 distinct chains · 35% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | G subunit Q (GI1-gq chimeric) | protein | 230 | 50% helix, 18% strand | — |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 341 | 9% helix, 47% strand | P54311 |
| D | Arg-pro-pro-gly-phe-ser-pro-phe-arg | protein | 9 | 0% helix, 0% strand | — |
| R | B2 bradykinin receptor | protein | 287 | 79% helix, 4% strand | P30411 |
| S | Single Fab chain (SVFV16) | protein | 232 | 4% helix, 47% strand | — |
| Y | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 51 | 53% helix, 0% strand | P63212 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1064 | 0.81 | 0.82 | 68 | empty |
| 2 | 549 | 0.80 | 0.86 | 52 | empty |
| 3 | 165 | 0.55 | 0.81 | 31 | empty |
| 4 | 173 | 0.50 | 0.77 | 22 | empty |
| 5 | 95 | 0.44 | 0.79 | 19 | empty |
Interfaces
7 interfaces between chains.
- B–Y · 2095 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1528 Ų buried · 19 hydrogen bonds · protein-protein
- A–R · 1287 Ų buried · 18 hydrogen bonds · protein-protein
- D–R · 929 Ų buried · 15 hydrogen bonds · protein-protein
- A–S · 594 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7F2O · Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an… · the same entry in another collection · chain Y against Y, TM-score 1.00
- P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P30411 · AlphaFold monomer V2.0 prediction for B2 bradykinin receptor (P30411) · a predicted model of the same protein · chain R against A, TM-score 0.94
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain Y against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54311
- Every structure of UniProt P30411
- Every structure of UniProt P63212
- Elsewhere: RCSB PDB 7F2O · PDBe 7F2O · UniProt P54311 · UniProt P30411 · UniProt P63212
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