Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with minigs protein

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• CLR · Cholesterol · ligand · 5 copies · chains R
• PLM · Palmitic acid · ligand · 4 copies · chains R
• LDP · L-dopamine · ligand · chains R
• G4C · 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7LJD · Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex… · the same entry in another collection · chain N against N, TM-score 1.00
• P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
• P21728 · AlphaFold monomer V2.0 prediction for D(1A) dopamine receptor (P21728) · a predicted model of the same protein · chain R against A, TM-score 0.89
• P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.67

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P21728
• Every structure of UniProt P54311
• Every structure of UniProt P63212
• Elsewhere: RCSB PDB 7LJD · PDBe 7LJD · UniProt P21728 · UniProt P54311 · UniProt P63212