UniProt P21728
D(1A) dopamine receptor (P21728)
D(1A) dopamine receptor (UniProt P21728): 22 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P21728
- Protein
- D(1A) dopamine receptor
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 21 · 4 records with a druggable one
Structures
23 records of P21728 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7CKW | Cryo-EM structure of fenoldopam bound dopamine receptor DRD1-gs signaling complex | electron microscopy | R | G3C, CLR | — |
| 7CKX | Cryo-EM structure of A77636 bound dopamine receptor DRD1-gs signaling complex | electron microscopy | R | G3O, CLR | — |
| 7CKY | Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex | electron microscopy | R | CLR, G3U | 5 (best 0.78) |
| 7CKY | Cryo-EM structure of PW0464 bound dopamine receptor DRD1-gs signaling complex | electron microscopy | R | CLR, G3U | — |
| 7CRH | Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-Gs signaling complex | electron microscopy | R | GBU | 6 (best 0.79) |
| 7CRH | Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-gs signaling complex | electron microscopy | R | GBU | — |
| 7F0T | Cryo-EM structure of dopamine receptor 1 and mini-gs complex with dopamine bound | electron microscopy | F | LDP | — |
| 7F1O | Cryo-EM structure of the GDP-bound dopamine receptor 1 and mini-gs complex with NB35 | electron microscopy | F | LDP | — |
| 7F1Z | Cryo-EM structure of the GDP-bound dopamine receptor 1 and mini-gs complex without NB35 | electron microscopy | F | LDP | — |
| 7F23 | Cryo-EM structure of the GTP-bound dopamine receptor 1 and mini-gs complex with NB35 | — | — | — | |
| 7F24 | Cryo-EM structure of the GTP-bound dopamine receptor 1 and mini-gs complex without NB35 | electron microscopy | F | LDP | — |
| 7JOZ | Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist | x-ray diffraction | R | VFP | — |
| 7JV5 | Cryo-EM structure of skf-81297-bound dopamine receptor 1 in complex with gs protein | electron microscopy | R | SK0, CLR, PLM | — |
| 7JVP | Cryo-EM structure of skf-83959-bound dopamine receptor 1 in complex with gs protein | electron microscopy | R | SK9, CLR, PLM | — |
| 7JVQ | Cryo-EM structure of apomorphine-bound dopamine receptor 1 in complex with gs protein | electron microscopy | R | OR9, CLR, PLM | — |
| 7LJC | Allosteric modulator LY3154207 binding to skf-81297-bound dopamine receptor 1 in complex with… | electron microscopy | R | SK0, G4C, CLR, PLM | — |
| 7LJD | Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with minigs… | electron microscopy | R | LDP, G4C, CLR, PLM | — |
| 7X2C | Cryo-EM structure of the fenoldopam-bound D1 dopamine receptor and mini-Gs complex | electron microscopy | F | CLR, G3C | 5 (best 0.76) |
| 7X2C | Cryo-EM structure of the fenoldopam-bound D1 dopamine receptor and mini-gs complex | electron microscopy | F | CLR, G3C | — |
| 7X2D | Cryo-EM structure of the tavapadon-bound D1 dopamine receptor and mini-gs complex | electron microscopy | F | CLR, 86W | — |
| 7X2F | Cryo-EM structure of the dopamine and LY3154207-bound D1 dopamine receptor and mini-gs complex | electron microscopy | F | CLR, G4C, LDP | — |
| 8JXS | Structure of nanobody-bound DRD1_PF-6142 complex | electron microscopy | A | V6X | 5 (best 0.78) |
| P21728 | AlphaFold monomer V2.0 prediction for D(1A) dopamine receptor (P21728) | predicted | A | — | — |
Ligands
- CLR · Cholesterol · in 13 records
- LDP · L-dopamine · in 6 records
- PLM · Palmitic acid · in 5 records
- G3C · (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol · in 3 records
- G4C · 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone · in 3 records
- G3U · 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione · in 2 records
- GBU · (1S)-6-chloranyl-3-methyl-1-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol · in 2 records
- SK0 · (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol · in 2 records
- 86W · 1,5-dimethyl-6-[2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]oxy-phenyl]pyrimidine-2,4-dione · in 1 record
- G3O · (1R,3S)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol · in 1 record
- OR9 · (6AR)-6-methyl-5,6,6A,7-tetrahydro-4H-dibenzo[de, g]quinoline-10,11-diol · in 1 record
- SK9 · (1R)-6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol · in 1 record
- V6X · 4-[3-methyl-4-(6-methylimidazo[1,2-a]pyrazin-5-yl)phenoxy]furo[3,2-c]pyridine · in 1 record
- VFP · 6-{4-[(furo[3,2-c]pyridin-4-yl)oxy]-2-methylphenyl}-1, 5-dimethylpyrimidine-2,4(1H,3H)-dione · in 1 record
Experiment against prediction
- 8JXS chain A against the predicted model P21728: TM-score 0.91, RMSD 2.30 Å
- 7F24 chain F against the predicted model P21728: TM-score 0.91, RMSD 2.23 Å
- 7F1Z chain F against the predicted model P21728: TM-score 0.91, RMSD 2.35 Å
- 7X2D chain F against the predicted model P21728: TM-score 0.91, RMSD 2.40 Å
- 7F1O chain F against the predicted model P21728: TM-score 0.90, RMSD 2.36 Å
- 7JVP chain R against the predicted model P21728: TM-score 0.90, RMSD 2.44 Å
- 7LJC chain R against the predicted model P21728: TM-score 0.90, RMSD 2.41 Å
- 7CKX chain R against the predicted model P21728: TM-score 0.90, RMSD 2.37 Å
- 7X2F chain F against the predicted model P21728: TM-score 0.90, RMSD 2.55 Å
- 7JV5 chain R against the predicted model P21728: TM-score 0.89, RMSD 2.57 Å
Elsewhere
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