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Ligand · SK0

SK0 · (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol

SK0, (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol (C16 H16 Cl N O2, 289.8 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
SK0
Formula
C16 H16 Cl N O2
Class
ligand
Structures
4
PDB entries
2

Binding sites

SK0 in 4 structures; the first of them:

  • 7JV5 · Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein · SK0 R501 · binds VAL100, ASP103, ILE104, SER107, THR108, SER188, LEU190, TYR194 and 9 more
  • 7LJC · Allosteric modulator LY3154207 binding to SKF-81297-bound dopamine receptor 1 in complex… · SK0 R501 · binds VAL100, ASP103, ILE104, SER107, THR108, SER188, LEU190, TYR194 and 10 more
  • 7JV5 · Cryo-EM structure of skf-81297-bound dopamine receptor 1 in complex with gs protein · SK0 R501 · binds VAL100, ASP103, ILE104, SER107, THR108, SER188, LEU190, TYR194 and 9 more
  • 7LJC · Allosteric modulator LY3154207 binding to skf-81297-bound dopamine receptor 1 in complex… · SK0 R501 · binds VAL100, ASP103, ILE104, SER107, THR108, SER188, LEU190, TYR194 and 10 more

Residues it binds most

SER 4, PHE 4, TRP 4, VAL 4, ASN 4, ASP 4, ILE 4, LEU 4, THR 4, TYR 4 (residue and the binding sites it lines).

Found with

  • CLR · Cholesterol
  • PLM · Palmitic acid
  • G4C · 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone

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