G4C · 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone

Binding sites

G4C in 6 structures; the first of them:

• 7CKZ · Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling… · G4C R503 · binds LEU112, CYS115, VAL119, TRP123, ARG130, LEU143, VAL146, ILE209
• 7LJD · Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex… · G4C R502 · binds TRP123, SER127, ARG130, TYR131, LYS134, MET135, LYS138, ALA139 and 2 more
• 7X2F · Cryo-EM structure of the dopamine and LY3154207-bound D1 dopamine receptor and mini-Gs… · G4C F502 · binds TRP123, SER127, ARG130, TYR131, LYS134, MET135, LYS138, ALA139 and 2 more
• 7LJC · Allosteric modulator LY3154207 binding to skf-81297-bound dopamine receptor 1 in complex… · G4C R502 · binds TRP123, SER127, ARG130, TYR131, LYS134, MET135, LYS138, ILE142
• 7LJD · Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex… · G4C R502 · binds TRP123, SER127, ARG130, LYS134, MET135, LYS138, ALA139, ILE142
• 7X2F · Cryo-EM structure of the dopamine and LY3154207-bound D1 dopamine receptor and mini-gs… · G4C F502 · binds TRP123, SER127, ARG130, LYS134, LYS138, ALA139, ILE142, LEU143

Residues it binds most

LYS 5, ARG 6, ILE 6, TRP 6, LEU 4, SER 5, ALA 4, MET 4, TYR 3, VAL 1 (residue and the binding sites it lines).

Found with

• CLR · Cholesterol
• LDP · L-dopamine
• PLM · Palmitic acid
• SK0 · (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol