MolNFT v1 · #190414 · protein
Cryo-EM structure of the tavapadon-bound D1 dopamine receptor and mini-gs complex
7X2D: “Cryo-EM structure of the tavapadon-bound D1 dopamine receptor and mini-gs complex”. Electron microscopy, 2 ligands (CLR, 86W). MolNFT v1 #190414 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7X2D
- Type
- protein
- Length
- 1,032 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P21728, P62873, P59768
- Ligands
- CLR, 86W
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F | — | protein | 280 | — | P21728 |
| A | — | protein | 229 | — | — |
| B | — | protein | 339 | — | P62873 |
| D | — | protein | 56 | — | P59768 |
| E | — | protein | 128 | — | — |
Ligands and binding sites
- CLR · Cholesterol · ligand · chains F
- 86W · 1,5-dimethyl-6-[2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]oxy-phenyl]pyrimidine-2,4-dione · ligand · chains F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7X2D · Cryo-EM structure of the tavapadon-bound D1 dopamine receptor and mini-Gs complex · the same entry in another collection · chain E against E, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain D against A, TM-score 0.94
- P21728 · AlphaFold monomer V2.0 prediction for D(1A) dopamine receptor (P21728) · a predicted model of the same protein · chain F against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21728
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7X2D · PDBe 7X2D · UniProt P21728 · UniProt P62873 · UniProt P59768
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