UniProt P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (UniProt P62873): 683 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 2,244 pockets. Binding sites, druggability and experiment against…
- UniProt
- P62873
- Protein
- Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
- Experimental structures
- 683
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 2,244 · 347 records with a druggable one
Structures
684 records of P62873 in the MolNFT archive: 683 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4KFM | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with… | x-ray diffraction | B | — | — |
| 4KFM | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (KIR3.2) in complex with… | x-ray diffraction | B | — | — |
| 4PNK | G protein-coupled receptor kinase 2 in complex with GSK180736A | x-ray diffraction | B | — | — |
| 4PNK | G protein-coupled receptor kinase 2 in complex with GSK180736A | x-ray diffraction | B | — | — |
| 5HE0 | Bovine GRK2 in complex with Gbetagamma subunits and CCG215022 | x-ray diffraction | B | — | — |
| 5HE0 | Bovine GRK2 in complex with gbetagamma subunits and CCG215022 | x-ray diffraction | B | — | — |
| 5HE1 | Human GRK2 in complex with Gbetagamma subunits and CCG224062 | x-ray diffraction | B | — | — |
| 5HE1 | Human GRK2 in complex with gbetagamma subunits and CCG224062 | x-ray diffraction | B | — | — |
| 5HE2 | Bovine GRK2 in complex with Gbetagamma subunits and CCG224406 | x-ray diffraction | B | — | 4 (best 0.79) |
| 5HE2 | Bovine GRK2 in complex with gbetagamma subunits and CCG224406 | x-ray diffraction | B | — | — |
| 5HE3 | Bovine GRK2 in complex with gbetagamma subunits and CCG224411 | x-ray diffraction | B | — | — |
| 5UKK | Human GRK2 in complex with human G-beta-gamma subunits and CCG211998 (14ak) | x-ray diffraction | B | — | — |
| 5UKK | Human GRK2 in complex with human G-beta-gamma subunits and CCG211998 (14AK) | x-ray diffraction | B | — | — |
| 5UKL | Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd) | x-ray diffraction | B | — | 3 (best 0.79) |
| 5UKL | Human GRK2 in complex with gbetagamma subunits and CCG222886 (14BD) | x-ray diffraction | B | — | — |
| 5UKM | Bovine GRK2 in complex with human gbetagamma subunits and CCG258208 (14AS) | x-ray diffraction | B | — | — |
| 5UZ7 | Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs… | electron microscopy | B | — | 5 (best 0.85) |
| 5UZ7 | Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs… | electron microscopy | B | — | — |
| 6B3J | 3.3 ångström phase-plate cryo-EM structure of a biased agonist-bound human glp-1 receptor-gs complex | electron microscopy | B | — | — |
| 6CRK | Heterotrimeric G-protein in complex with an antibody fragment | x-ray diffraction | B | — | 7 (best 0.82) |
| 6CRK | Heterotrimeric G-protein in complex with an antibody fragment | x-ray diffraction | B | — | — |
| 6D9H | Cryo-EM structure of the human adenosine A1 receptor-GI2-protein complex bound to its endogenous… | electron microscopy | B | — | — |
| 6DDE | Mu opioid receptor-gi protein complex | electron microscopy | B | — | — |
| 6DDF | Mu Opioid Receptor-Gi Protein Complex | electron microscopy | B | — | 3 (best 0.82) |
| 6DDF | Mu opioid receptor-gi protein complex | electron microscopy | B | — | — |
| 6E3Y | Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor | electron microscopy | B | — | 7 (best 0.81) |
| 6E3Y | Cryo-EM structure of the active, gs-protein complexed, human cgrp receptor | electron microscopy | B | — | — |
| 6EG8 | Structure of the GDP-bound Gs heterotrimer | x-ray diffraction | A, B, D, F | — | 20 (best 0.83) |
| 6EG8 | Structure of the GDP-bound gs heterotrimer | x-ray diffraction | A, B, D, F | — | — |
| 6G79 | Coupling specificity of heterotrimeric go to the serotonin 5-HT1B receptor | electron microscopy | B | — | — |
| 6GDG | Cryo-EM structure of the adenosine A2A receptor bound to a miniGs heterotrimer | electron microscopy | B | — | 6 (best 0.80) |
| 6GDG | Cryo-EM structure of the adenosine A2A receptor bound to a minigs heterotrimer | electron microscopy | B | — | — |
| 6KPF | Cryo-EM structure of a class A GPCR with G protein complex | electron microscopy | B | — | — |
| 6KPF | Cryo-EM structure of a class a GPCR with G protein complex | electron microscopy | B | — | — |
| 6KPG | Cryo-EM structure of CB1-G protein complex | electron microscopy | B | — | — |
| 6KPG | Cryo-EM structure of CB1-G protein complex | electron microscopy | B | — | — |
| 6LFM | Cryo-EM structure of a class a GPCR | electron microscopy | B | — | — |
| 6LFO | Cryo-EM structure of a class A GPCR monomer | electron microscopy | B | — | — |
| 6LFO | Cryo-EM structure of a class a GPCR monomer | electron microscopy | B | — | — |
| 6LI3 | Cryo-EM structure of GPR52-minigs-NB35 | electron microscopy | B | — | — |
| 6LMK | Cryo-EM structure of the human glucagon receptor in complex with gs | electron microscopy | B | — | — |
| 6LML | Cryo-EM structure of the human glucagon receptor in complex with GI1 | electron microscopy | B | — | — |
| 6M1H | Cryoem structure of human PAC1 receptor in complex with maxadilan | electron microscopy | E | — | — |
| 6M1I | CryoEM structure of human PAC1 receptor in complex with PACAP38 | electron microscopy | E | — | — |
| 6M1I | Cryoem structure of human PAC1 receptor in complex with PACAP38 | electron microscopy | E | — | — |
| 6M8S | Crystal structure of the KCTD12 H1 domain in complex with GBETA1GAMMA2 subunits | x-ray diffraction | C, D, G, H, K | — | — |
| 6N4B | Cannabinoid receptor 1-G protein complex | electron microscopy | B | — | — |
| 6NI3 | B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex | electron microscopy | B | — | — |
| 6NI3 | B2V2R-gs protein subcomplex of a GPCR-G protein-beta-arrestin mega- complex | electron microscopy | B | — | — |
| 6NIY | A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs… | electron microscopy | B | — | 6 (best 0.84) |
| 6NIY | A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs… | electron microscopy | B | — | — |
| 6OIJ | Muscarinic acetylcholine receptor 1-G11 protein complex | electron microscopy | B | — | 6 (best 0.83) |
| 6OIJ | Muscarinic acetylcholine receptor 1-G11 protein complex | electron microscopy | B | — | — |
| 6OIK | Muscarinic acetylcholine receptor 2-Go complex | electron microscopy | B | — | 5 (best 0.82) |
| 6OIK | Muscarinic acetylcholine receptor 2-go complex | electron microscopy | B | — | — |
| 6OMM | Cryo-EM structure of formyl peptide receptor 2/LIPOXIN A4 receptor in complex with gi | electron microscopy | B | — | — |
| 6ORV | Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor | electron microscopy | BP | — | 10 (best 0.81) |
| 6OS9 | human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) | electron microscopy | B | — | 5 (best 0.81) |
| 6OS9 | Human neurotensin receptor 1 (HNTSR1) - GI1 protein complex in canonical conformation (C state) | electron microscopy | B | — | — |
| 6OSA | Human neurotensin receptor 1 (HNTSR1) - GI1 protein complex in non- canonical conformation (nc… | electron microscopy | B | — | — |
624 records more on the page itself.
Ligands
- PLM · Palmitic acid · in 1 record
Experiment against prediction
- 8F0J chain B against the predicted model P62873: TM-score 1.00, RMSD 0.36 Å
- 8FMZ chain C against the predicted model P62873: TM-score 1.00, RMSD 0.37 Å
- 8E3Y chain B against the predicted model P62873: TM-score 1.00, RMSD 0.37 Å
- 7LD3 chain B against the predicted model P62873: TM-score 1.00, RMSD 0.37 Å
- 6X18 chain B against the predicted model P62873: TM-score 1.00, RMSD 0.38 Å
- 7VIF chain A against the predicted model P62873: TM-score 1.00, RMSD 0.39 Å
- 7S8M chain C against the predicted model P62873: TM-score 1.00, RMSD 0.39 Å
- 8DZP chain C against the predicted model P62873: TM-score 1.00, RMSD 0.39 Å
- 7TYF chain B against the predicted model P62873: TM-score 1.00, RMSD 0.39 Å
- 7TYF chain B against the predicted model P62873: TM-score 1.00, RMSD 0.39 Å
Elsewhere
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