Cryo-EM structure of the human growth hormone-releasing hormone receptor-gs protein complex

Structure

electron microscopy · 6 distinct chains.

Ligands and binding sites

• PLM · Palmitic acid · ligand · 2 copies · chains R, A
• CLR · Cholesterol · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
• Q02643 · AlphaFold monomer V2.0 prediction for growth hormone-releasing hormone receptor (Q02643) · a predicted model of the same protein · chain R against A, TM-score 0.94
• P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.67

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q02643
• Every structure of UniProt P63092
• Every structure of UniProt P01286
• Every structure of UniProt P54311
• Every structure of UniProt P63212
• Elsewhere: RCSB PDB 7CZ5 · PDBe 7CZ5 · UniProt Q02643 · UniProt P63092 · UniProt P01286 · UniProt P54311 · UniProt P63212