MolNFT v1 · #177677 · protein
GPR114-gs-SCFV16 complex
7EQ1 · Gs protein alpha subunit: “GPR114-gs-SCFV16 complex”. Electron microscopy, 14 pockets (best druggability 0.82). MolNFT v1 #177677 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EQ1
- Type
- protein
- Length
- 1,150 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gs protein alpha subunit; Adhesion G-protein coupled receptor G5; SCFV16; Guanine…
- UniProt
- Q8IZF4, P63212, P54311
- Pockets
- 14 · best druggability 0.82
Structure
electron microscopy · 5 distinct chains · 31% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gs protein alpha subunit | protein | 237 | 46% helix, 16% strand | — |
| R | Adhesion G-protein coupled receptor G5 | protein | 284 | 63% helix, 1% strand | Q8IZF4 |
| S | SCFV16 | protein | 233 | 4% helix, 47% strand | — |
| Y | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 58 | 53% helix, 0% strand | P63212 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 7% helix, 47% strand | P54311 |
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 661 | 0.82 | 0.87 | 55 | empty |
| 2 | 1080 | 0.79 | 0.81 | 85 | empty |
| 3 | 240 | 0.57 | 0.79 | 43 | empty |
| 4 | 224 | 0.53 | 0.77 | 32 | empty |
| 5 | 80 | 0.52 | 0.85 | 23 | empty |
Interfaces
6 interfaces between chains.
- Y–B · 2190 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1480 Ų buried · 17 hydrogen bonds · protein-protein
- A–R · 1372 Ų buried · 13 hydrogen bonds · protein-protein
- A–S · 620 Ų buried · 12 hydrogen bonds · protein-protein
- S–B · 451 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7EQ1 · GPR114-Gs-scFv16 complex · the same entry in another collection · chain B against B, TM-score 1.00
- P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q8IZF4 · AlphaFold monomer V2.0 prediction for adhesion G-protein coupled receptor G5 (Q8IZF4) · a predicted model of the same protein · chain R against A, TM-score 0.91
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain Y against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IZF4
- Every structure of UniProt P63212
- Every structure of UniProt P54311
- Elsewhere: RCSB PDB 7EQ1 · PDBe 7EQ1 · UniProt Q8IZF4 · UniProt P63212 · UniProt P54311
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