MolNFT v1 · #178512 · protein
Luteinizing HORMONE/CHORIOGONADOTROPIN RECEPTOR(S277I)-chorionic gonadotropin-gs-ORG43553 complex
7FIH: “Luteinizing HORMONE/CHORIOGONADOTROPIN RECEPTOR(S277I)-chorionic gonadotropin-gs-ORG43553 complex”. Electron microscopy, 1 ligand (55Z). MolNFT v1 #178512 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7FIH
- Type
- protein
- Length
- 1,381 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P54311, P63212, P22888, P01215, P0DN86
- Ligands
- 55Z
Structure
electron microscopy · 6 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 238 | — | — |
| B | — | protein | 338 | — | P54311 |
| G | — | protein | 57 | — | P63212 |
| R | — | protein | 550 | — | P22888 |
| X | — | protein | 88 | — | P01215 |
| Y | — | protein | 110 | — | P0DN86 |
Ligands and binding sites
- 55Z · 5-azanyl-N-tert-butyl-2-methylsulfanyl-4-[3-(2-morpholin-4-ylethanoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7FIH · luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553… · the same entry in another collection · chain Y against Y, TM-score 1.00
- P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P22888 · AlphaFold monomer V2.0 prediction for lutropin-choriogonadotropic hormone receptor… · a predicted model of the same protein · chain R against A, TM-score 0.94
- P01215 · AlphaFold monomer V2.0 prediction for glycoprotein hormones alpha chain (P01215) · a predicted model of the same protein · chain X against A, TM-score 0.94
- P0DN86 · AlphaFold monomer V2.0 prediction for choriogonadotropin subunit beta 3 (P0DN86) · a predicted model of the same protein · chain Y against A, TM-score 0.90
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54311
- Every structure of UniProt P63212
- Every structure of UniProt P22888
- Every structure of UniProt P01215
- Every structure of UniProt P0DN86
- Elsewhere: RCSB PDB 7FIH · PDBe 7FIH · UniProt P54311 · UniProt P63212 · UniProt P22888 · UniProt P01215 · UniProt P0DN86
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