UniProt Q24451
Alpha-mannosidase 2 (Q24451)
Alpha-mannosidase 2 (UniProt Q24451), EC 3.2.1.114: 118 experimental structures on GenesisL1, 10 ligands bound, 44 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q24451
- Protein
- Alpha-mannosidase 2
- EC
- 3.2.1.114
- Experimental structures
- 118
- Predicted models
- 0
- Ligands
- 10
- Pockets
- 44 · 4 records with a druggable one
Structures
118 records of Q24451 in the MolNFT archive: 118 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HTY | Golgi alpha-mannosidase II | x-ray diffraction | A | — | — |
| 1HTY | Golgi alpha-mannosidase II | x-ray diffraction | A | — | — |
| 1HWW | Golgi alpha-mannosidase II in complex with swainsonine | x-ray diffraction | A | — | — |
| 1HWW | Golgi alpha-mannosidase II in complex with swainsonine | x-ray diffraction | A | — | — |
| 1HXK | Golgi alpha-mannosidase II in complex with deoxymannojirimicin | x-ray diffraction | A | — | — |
| 1HXK | Golgi alpha-mannosidase II in complex with deoxymannojirimicin | x-ray diffraction | A | — | — |
| 1PS3 | Golgi alpha-mannosidase II in complex with kifunensine | x-ray diffraction | A | — | — |
| 1PS3 | Golgi alpha-mannosidase II in complex with kifunensine | x-ray diffraction | A | — | — |
| 1QWN | GOLGI ALPHA-MANNOSIDASE II Covalent Intermediate Complex with 5-fluoro-gulosyl-fluoride | x-ray diffraction | A | — | — |
| 1QWN | Golgi alpha-mannosidase II covalent intermediate complex with 5- fluoro-gulosyl-fluoride | x-ray diffraction | A | — | — |
| 1QWU | Golgi alpha-mannosidase II D341N mutant complex with 5-F-guloside | x-ray diffraction | A | — | — |
| 1QWU | Golgi alpha-mannosidase II D341N mutant complex with 5-F-guloside | x-ray diffraction | A | — | — |
| 1QX1 | Golgi alpha-mannosidase II D341N mutant complex with 2-F-mannosyl-F | x-ray diffraction | A | — | — |
| 1QX1 | Golgi alpha-mannosidase II D341N mutant complex with 2-F-mannosyl-F | x-ray diffraction | A | — | — |
| 1R33 | Golgi alpha-mannosidase II complex with 5-thio-D-mannopyranosylamine | x-ray diffraction | A | — | — |
| 1R33 | Golgi alpha-mannosidase II complex with 5-thio-D-mannopyranosylamine | x-ray diffraction | A | — | — |
| 1R34 | Golgi alpha-mannosidase II complex with 5-thio-D-mannopyranosylamidinium salt | x-ray diffraction | A | — | — |
| 1R34 | Golgi alpha-mannosidase II complex with 5-thio-D- mannopyranosylamidinium salt | x-ray diffraction | A | — | — |
| 1TQS | Golgi alpha-Mannosidase II In Complex With Salacinol | x-ray diffraction | A | — | — |
| 1TQS | Golgi alpha-mannosidase II in complex with salacinol | x-ray diffraction | A | — | — |
| 1TQT | Golgi alpha-Mannosidase II In Complex With A Diastereomer of Salacinol | x-ray diffraction | A | — | — |
| 1TQT | Golgi alpha-mannosidase II in complex with a diastereomer of salacinol | x-ray diffraction | A | — | — |
| 1TQU | Golgi alpha-Mannosidase II In Complex With The Salacinol Analog Ghavamiol | x-ray diffraction | A | — | — |
| 1TQU | Golgi alpha-mannosidase II in complex with the salacinol analog ghavamiol | x-ray diffraction | A | — | — |
| 1TQV | Golgi alpha-Mannosidase II In Complex With Seleno-Salacinol (Blintol) | x-ray diffraction | A | — | — |
| 1TQV | Golgi alpha-mannosidase II in complex with seleno-salacinol (blintol) | x-ray diffraction | A | — | — |
| 1TQW | Golgi alpha-Mannosidase II In Complex With A Diastereomer of Seleno-Salacinol | x-ray diffraction | A | — | — |
| 1TQW | Golgi alpha-mannosidase II in complex with a diastereomer of seleno- salacinol | x-ray diffraction | A | — | — |
| 2ALW | Golgi alpha-mannosidase II complex with Noeuromycin | x-ray diffraction | A | — | — |
| 2ALW | Golgi alpha-mannosidase II complex with noeuromycin | x-ray diffraction | A | — | — |
| 2F7O | Golgi alpha-mannosidase II complex with mannostatin A | x-ray diffraction | A | — | — |
| 2F7O | Golgi alpha-mannosidase II complex with mannostatin a | x-ray diffraction | A | — | — |
| 2F7P | Golgi alpha-mannosidase II complex with benzyl-mannostatin A | x-ray diffraction | A | — | — |
| 2F7P | Golgi alpha-mannosidase II complex with benzyl-mannostatin a | x-ray diffraction | A | — | — |
| 2OW6 | Golgi alpha-mannosidase II complex with (1r,5s,6s,7r,8s)-1-thioniabicyclo[4.3.0]nonan-5,7,8-triol… | x-ray diffraction | A | — | — |
| 2OW6 | Golgi alpha-mannosidase II complex with (1R,5S,6S,7R,8S)-1- THIONIABICYCLO[4.3.0]NONAN-5,7,8-triol… | x-ray diffraction | A | — | — |
| 2OW7 | Golgi alpha-mannosidase II complex with (1R,6S,7R,8S)-1-thioniabicyclo[4.3.0]nonan-7,8-diol chloride | x-ray diffraction | A | — | — |
| 2OW7 | Golgi alpha-mannosidase II complex with (1R,6S,7R,8S)-1- THIONIABICYCLO[4.3.0]NONAN-7,8-diol… | x-ray diffraction | A | — | — |
| 3BLB | Crystal structure of Golgi Mannosidase II in complex with swainsonine at 1.3 Angstrom resolution | x-ray diffraction | A | — | — |
| 3BLB | Crystal structure of golgi mannosidase II in complex with swainsonine at 1.3 ångström resolution | x-ray diffraction | A | — | — |
| 3BUB | Golgi alpha-mannosidase II with an empty active site | x-ray diffraction | A | — | — |
| 3BUB | Golgi alpha-mannosidase II with an empty active site | x-ray diffraction | A | — | — |
| 3BUD | Golgi mannosidase II D204A catalytic nucleophile mutant with an empty active site | x-ray diffraction | A | — | — |
| 3BUD | Golgi mannosidase II D204A catalytic nucleophile mutant with an empty active site | x-ray diffraction | A | — | — |
| 3BUI | Golgi mannosidase II D204A catalytic nucleophile mutant complex with Tris | x-ray diffraction | A | — | — |
| 3BUI | Golgi mannosidase II D204A catalytic nucleophile mutant complex with tris | x-ray diffraction | A | — | — |
| 3BUP | Golgi alpha-mannosidase II D341N acid-base catalyst mutant with bound mannose | x-ray diffraction | A | — | — |
| 3BUP | Golgi alpha-mannosidase II D341N acid-base catalyst mutant with bound mannose | x-ray diffraction | A | — | — |
| 3BUQ | Golgi alpha-mannosidase II D204A catalytic nucleophile mutant with bound mannose. | x-ray diffraction | A | — | — |
| 3BUQ | Golgi alpha-mannosidase II D204A catalytic nucleophile mutant with bound mannose. | x-ray diffraction | A | — | — |
| 3BVT | GOLGI MANNOSIDASE II D204A catalytic nucleophile mutant complex with Methyl… | x-ray diffraction | A | — | — |
| 3BVT | Golgi mannosidase II D204A catalytic nucleophile mutant complex with methyl… | x-ray diffraction | A | — | — |
| 3BVU | GOLGI MANNOSIDASE II D204A catalytic nucleophile mutant complex with… | x-ray diffraction | A | — | — |
| 3BVU | Golgi mannosidase II D204A catalytic nucleophile mutant complex with… | x-ray diffraction | A | — | — |
| 3BVV | Golgi mannosidase II D204A catalytic nucleophile mutant complex with METHYL… | x-ray diffraction | A | — | — |
| 3BVV | Golgi mannosidase II D204A catalytic nucleophile mutant complex with methyl… | x-ray diffraction | A | — | — |
| 3BVW | GOLGI MANNOSIDASE II D204A catalytic nucleophile mutant complex with Methyl… | x-ray diffraction | A | — | — |
| 3BVW | Golgi mannosidase II D204A catalytic nucleophile mutant complex with methyl… | x-ray diffraction | A | — | — |
| 3BVX | GOLGI MANNOSIDASE II D204A catalytic nucleophile mutant complex with Methyl… | x-ray diffraction | A | — | — |
| 3BVX | Golgi mannosidase II D204A catalytic nucleophile mutant complex with methyl… | x-ray diffraction | A | — | — |
58 records more on the page itself.
Ligands
- ZN · Zinc ion · in 15 records
- KFE · (2~{S},3~{R},4~{S},5~{R})-~{N}-[5-(1-adamantylmethoxy) pentyl]-5-(hydroxymethyl)-3,4-bis(oxidanyl) pyrrolidine-2-carboxamide · in 2 records
- KG8 · (5~{R},6~{R},7~{S},8~{S})-5-(hydroxymethyl)-2-(3-phenylpropyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6,7,8-triol · in 2 records
- KGH · (1~{R},2~{S},3~{R},4~{R},5~{S},6~{R})-5-azanyl-6-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol · in 2 records
- A1IGB · amide modified swainsonine-configured alkyl indolizidine · in 1 record
- KFT · (2~{S},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)-~{N}-pentyl-pyrrolidine-2-carboxamide · in 1 record
- KFW · (2~{S},3~{R})-2-(hydroxymethyl)piperidin-3-ol · in 1 record
- KG5 · (2~{R},3~{R},4~{R},5~{S})-1-[5-[[4-(3,4-dihydro-2~{H}-1,5-benzodioxepin-7-yl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol · in 1 record
- KGB · (2~{S},3~{S},4~{R})-2-(hydroxymethyl)-1-(2-phenylmethoxyethyl)piperidine-3,4,5-triol · in 1 record
- KGE · (2~{S},3~{R})-2-(hydroxymethyl)-1,2,3,6-tetrahydropyridin-3-ol · in 1 record
Elsewhere
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