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Ligand · SWA

SWA · 1S-8AB-octahydro-indolizidine-1A,2A,8B-triol

SWA, 1S-8AB-octahydro-indolizidine-1A,2A,8B-triol (C8 H15 N O3, 173.2 g/mol), in the MolNFT structures on GenesisL1: bound in 9 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
SWA
Formula
C8 H15 N O3
Class
ligand
Structures
9
PDB entries
5

Binding sites

SWA in 9 structures; the first of them:

  • 1HWW · Golgi alpha-mannosidase II in complex with swainsonine · SWA A1103 · binds HIS90, ASP92, TRP95, ASP204, PHE206, ARG228, TYR269, ASP341 and 6 more
  • 2WW0 · Structure of the Family GH92 Inverting Mannosidase BT3990 from Bacteroides… · SWA A801 · binds SER86, TRP88, ILE89, TRP347, ASP348, TRP385, CYS393, MET394 and 5 more
  • 2WW2 · Structure of the Family GH92 Inverting Mannosidase BT2199 from Bacteroides… · SWA B900 · binds SER92, TRP94, ILE95, TRP353, ASP354, TRP391, CYS399, MET400 and 2 more
  • 2WYI · Structure of the Streptococcus pyogenes family GH38 alpha-mannosidase complexed with… · SWA A1907 · binds HIS13, ASP15, TRP18, ASP125, PHE127, ARG149, TYR192, ASP232 and 6 more
  • 3BLB · Crystal structure of Golgi Mannosidase II in complex with swainsonine at 1.3 Angstrom… · SWA A1048 · binds HIS90, ASP92, TRP95, ASP204, PHE206, ARG228, TYR269, ASP341 and 6 more
  • 1HWW · Golgi alpha-mannosidase II in complex with swainsonine · SWA A1103 · binds HIS90, ASP92, TRP95, ASP204, PHE206, ARG228, TYR269, ASP341 and 6 more
  • 2WW0 · Structure of the family GH92 inverting mannosidase BT3990 from bacteroides… · SWA A801 · binds SER86, TRP88, ILE89, TRP347, ASP348, TRP385, CYS393, MET394 and 5 more
  • 2WW2 · Structure of the family GH92 inverting mannosidase BT2199 from bacteroides… · SWA B900 · binds SER92, TRP94, ILE95, TRP353, ASP354, TRP391, CYS399, MET400 and 2 more
  • 2WYI · Structure of the streptococcus pyogenes family GH38 alpha- mannosidase complexed with… · SWA A1907 · binds HIS13, ASP15, TRP18, ASP125, PHE127, ARG149, TYR192, ASP232 and 6 more

Residues it binds most

ASP 25, TRP 25, GLU 18, CYS 20, MET 18, ASN 16, GLN 16, SER 16, HIS 7, ILE 14 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • GOL · Glycerol
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • MRD · (4R)-2-methylpentane-2,4-diol
  • CA · Calcium ion
  • NA · Sodium ion
  • MPD · (4S)-2-methyl-2,4-pentanediol
  • PG0 · 2-(2-methoxyethoxy)ethanol

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