UniProt P19491
Glutamate receptor 2 (P19491)
Glutamate receptor 2 (UniProt P19491): 511 experimental structures and 1 predicted model on GenesisL1, 59 ligands bound, 994 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P19491
- Protein
- Glutamate receptor 2
- Experimental structures
- 511
- Predicted models
- 1
- Ligands
- 59
- Pockets
- 994 · 67 records with a druggable one
Structures
512 records of P19491 in the MolNFT archive: 511 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FTJ | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with glutamate at 1.9… | x-ray diffraction | A, B, C | — | — |
| 1FTJ | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with glutamate at 1.9… | x-ray diffraction | A, B, C | — | — |
| 1FTK | Crystal structure of the GLUR2 ligand binding core (S1S2I) in complex with kainate at 1.6 a… | x-ray diffraction | A | — | — |
| 1FTK | Crystal structure of the GLUR2 ligand binding core (S1S2I) in complex with kainate at 1.6 a… | x-ray diffraction | A | — | — |
| 1FTL | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with the antagonist dnqx at… | x-ray diffraction | A, B | — | — |
| 1FTL | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with the antagonist dnqx at… | x-ray diffraction | A, B | — | — |
| 1FTM | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with AMPA at 1.7 resolution | x-ray diffraction | A, B, C | — | — |
| 1FTM | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with AMPA at 1.7 resolution | x-ray diffraction | A, B, C | — | — |
| 1FTO | Crystal structure of the GLUR2 ligand binding core (S1S2J) in the apo state at 2.0 a resolution | x-ray diffraction | A, B | — | — |
| 1FTO | Crystal structure of the GLUR2 ligand binding core (S1S2J) in the apo state at 2.0 a resolution | x-ray diffraction | A, B | — | — |
| 1FW0 | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with kainate at 2.0 a… | x-ray diffraction | A | — | — |
| 1FW0 | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with kainate at 2.0 a… | x-ray diffraction | A | — | — |
| 1GR2 | Structure of a glutamate receptor ligand binding core (GLUR2) complexed with kainate | x-ray diffraction | A | — | — |
| 1GR2 | Structure of a glutamate receptor ligand binding core (GLUR2) complexed with kainate | x-ray diffraction | A | — | — |
| 1LB8 | Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in… | x-ray diffraction | A, B | — | — |
| 1LB8 | Crystal structure of the non-desensitizing GLUR2 ligand binding core mutant (S1S2J-L483Y) in… | x-ray diffraction | A, B | — | — |
| 1LB9 | Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in… | x-ray diffraction | A, B | — | — |
| 1LB9 | Crystal structure of the non-desensitizing GLUR2 ligand binding core mutant (S1S2J-L483Y) in… | x-ray diffraction | A, B | — | — |
| 1LBB | Crystal structure of the GluR2 ligand binding domain mutant (S1S2J-N754D) in complex with kainate… | x-ray diffraction | A | — | — |
| 1LBB | Crystal structure of the GLUR2 ligand binding domain mutant (S1S2J- N754D) in complex with kainate… | x-ray diffraction | A | — | — |
| 1LBC | Crystal structure of GLUR2 ligand binding core (S1S2J- N775S) in complex with cyclothiazide (ctz)… | x-ray diffraction | A, B, C | — | — |
| 1M5B | X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH 2-Me-Tet-AMPA AT 1.85 A… | x-ray diffraction | A, B, C | — | — |
| 1M5B | X-ray structure of the GLUR2 ligand binding core (S1S2J) in complex with 2-me-tet-AMPA at 1.85 a… | x-ray diffraction | A, B, C | — | — |
| 1M5C | X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH Br-HIBO AT 1.65 A… | x-ray diffraction | A | — | — |
| 1M5C | X-ray structure of the GLUR2 ligand binding core (S1S2J) in complex with br-hibo at 1.65 a… | x-ray diffraction | A | — | — |
| 1M5D | X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH Br-HIBO AT 1.73 A… | x-ray diffraction | A | — | — |
| 1M5D | X-ray structure of the GLUR2 ligand binding core (S1S2J-Y702F) in complex with br-hibo at 1.73 a… | x-ray diffraction | A | — | — |
| 1M5E | X-ray structure of the GLUR2 ligand binding core (S1S2J) in complex with acpa at 1.46 a resolution | x-ray diffraction | A, B, C | — | — |
| 1M5E | X-ray structure of the GLUR2 ligand binding core (S1S2J) in complex with acpa at 1.46 a resolution | x-ray diffraction | A, B, C | — | — |
| 1M5F | X-ray structure of the GLUR2 ligand binding core (S1S2J-Y702F) in complex with acpa at 1.95 a… | x-ray diffraction | A, B, C | — | — |
| 1M5F | X-ray structure of the GLUR2 ligand binding core (S1S2J-Y702F) in complex with acpa at 1.95 a… | x-ray diffraction | A, B, C | — | — |
| 1MM6 | crystal structure of the GluR2 ligand binding core (S1S2J) in complex with quisqualate in a non… | x-ray diffraction | A, B | — | — |
| 1MM6 | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with quisqualate in a non… | x-ray diffraction | A, B | — | — |
| 1MM7 | Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in a Zinc… | x-ray diffraction | A, B, C | — | — |
| 1MM7 | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with quisqualate in a zinc… | x-ray diffraction | A, B, C | — | — |
| 1MQD | X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A… | x-ray diffraction | A, B, C, D | — | — |
| 1MQD | X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (S)-des-me-AMPA at 1.46 a… | x-ray diffraction | A, B, C, D | — | — |
| 1MQG | Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Iodo-Willardiine at 2.15… | x-ray diffraction | A, B | — | — |
| 1MQG | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with iodo-willardiine at 2.15… | x-ray diffraction | A, B | — | — |
| 1MQH | Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Bromo-Willardiine at 1.8… | x-ray diffraction | A | — | — |
| 1MQH | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with bromo-willardiine at 1.8… | x-ray diffraction | A | — | — |
| 1MQI | Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Fluoro-Willardiine at… | x-ray diffraction | A | — | — |
| 1MQI | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with fluoro-willardiine at… | x-ray diffraction | A | — | — |
| 1MQJ | Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with willardiine at 1.65… | x-ray diffraction | A | — | — |
| 1MQJ | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with willardiine at 1.65… | x-ray diffraction | A | — | — |
| 1MS7 | X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A… | x-ray diffraction | A, B, C | — | — |
| 1MS7 | X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (S)-des-me-AMPA at 1.97 a… | x-ray diffraction | A, B, C | — | — |
| 1MXU | CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) in complex with bromo-willardiine… | x-ray diffraction | A, B, C | — | — |
| 1MXU | Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with bromo-willardiine… | x-ray diffraction | A, B, C | — | — |
| 1MXV | crystal titration experiments (AMPA co-crystals soaked in 10 mM BrW) | x-ray diffraction | A, B, C | — | — |
| 1MXV | Crystal titration experiments (AMPA co-crystals soaked in 10 mm brw) | x-ray diffraction | A, B, C | — | — |
| 1MXW | crystal titration experiments (AMPA co-crystals soaked in 1 mM BrW) | x-ray diffraction | A, B, C | — | — |
| 1MXW | Crystal titration experiments (AMPA co-crystals soaked in 1 mm brw) | x-ray diffraction | A, B, C | — | — |
| 1MXX | crystal titration experiments (AMPA co-crystals soaked in 100 uM BrW) | x-ray diffraction | A, B, C | — | — |
| 1MXX | Crystal titration experiments (AMPA co-crystals soaked in 100 um brw) | x-ray diffraction | A, B, C | — | — |
| 1MXY | crystal titration experiments (AMPA co-crystals soaked in 10 uM BrW) | x-ray diffraction | A, B, C | — | — |
| 1MXY | Crystal titration experiments (AMPA co-crystals soaked in 10 um brw) | x-ray diffraction | A, B, C | — | — |
| 1MXZ | crystal titration experiments (AMPA co-crystals soaked in 1 uM BrW) | x-ray diffraction | A, B, C | — | — |
| 1MXZ | Crystal titration experiments (AMPA co-crystals soaked in 1 um brw) | x-ray diffraction | A, B, C | — | — |
| 1MY0 | crystal titration experiments (AMPA co-crystals soaked in 100 nM BrW) | x-ray diffraction | A, B, C | — | — |
452 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 42 records
- SO4 · Sulfate ion · in 38 records
- ZK1 · {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid · in 36 records
- CL · Chloride ion · in 29 records
- CYZ · Cyclothiazide · in 27 records
- GLU · Glutamic acid · in 21 records
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 13 records
- LI · Lithium ion · in 11 records
- CLR · Cholesterol · in 10 records
- E2Q · 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide · in 10 records
- NA · Sodium ion · in 8 records
- QUS · (S)-2-amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid · in 8 records
- ZN · Zinc ion · in 8 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 7 records
- PAM · Palmitoleic acid · in 6 records
- SPD · Spermidine · in 6 records
- 6ZP · 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile · in 5 records
- AJP · Digitonin · in 5 records
- BMA · beta-D-mannopyranose · in 5 records
- D45 · 6,6'-(ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2, 4-benzothiadiazine 1,1-dioxide) · in 5 records
- FXW · 6,6'-(ethane-1,2-diyl)bis(4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) · in 5 records
- 79N · (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate · in 3 records
- BR · Bromide ion · in 3 records
- GYK · (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide · in 3 records
- 6ZQ · 3-(2-chlorophenyl)-2-(2-{6-[(diethylamino) methyl]pyridin-2-yl}ethyl)-6-fluoroquinazolin-4(3H)-one · in 2 records
- 7M6 · 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide · in 2 records
- 8VE · (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid · in 2 records
- 8VN · (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid · in 2 records
- 8WQ · (2~{S},3~{R},4~{R})-3-(carboxycarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylic acid · in 2 records
- 9TE · 4-cyclopropyl-7-(3-methoxyphenoxy)-2,3-dihydro-1$L^{6}, 2,4-benzothiadiazine 1,1-dioxide · in 2 records
Experiment against prediction
- 9B69 chain D against the predicted model P19491: TM-score 0.99, RMSD 0.53 Å
- 9B68 chain D against the predicted model P19491: TM-score 0.99, RMSD 0.54 Å
- 6U5S chain D against the predicted model P19491: TM-score 0.99, RMSD 0.56 Å
- 6U5S chain B against the predicted model P19491: TM-score 0.99, RMSD 0.56 Å
- 7OCC chain B against the predicted model P19491: TM-score 0.99, RMSD 0.58 Å
- 7OCC chain D against the predicted model P19491: TM-score 0.99, RMSD 0.58 Å
- 6U6I chain D against the predicted model P19491: TM-score 0.99, RMSD 0.59 Å
- 9B68 chain B against the predicted model P19491: TM-score 0.99, RMSD 0.63 Å
- 9B69 chain B against the predicted model P19491: TM-score 0.99, RMSD 0.65 Å
- 6U5S chain A against the predicted model P19491: TM-score 0.99, RMSD 0.68 Å
Elsewhere
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