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Ligand · ZK1

ZK1 · {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid

ZK1, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid (C14 H15 F3 N3 O6 P, 409.3 g/mol), in the MolNFT structures on GenesisL1: bound in 41 records (32 PDB entries). Every binding site…

Component
ZK1
Formula
C14 H15 F3 N3 O6 P
Class
ligand
Structures
41
PDB entries
32

Binding sites

ZK1 in 41 structures; the first of them:

  • 5KBT · Cryo-EM structure of GluA2-1xSTZ complex at 6.4 Angstrom resolution · ZK1 A1301 · binds GLU402, TYR405, TYR450, PRO478, LEU479, THR480, ARG485, GLY653 and 6 more
  • 5KBU · Cryo-EM structure of GluA2-2xSTZ complex at 7.8 Angstrom resolution · ZK1 A1301 · binds GLU402, TYR405, TYR450, PRO478, LEU479, THR480, ARG485, GLY653 and 6 more
  • 5KBV · Cryo-EM structure of GluA2 bound to antagonist ZK200775 at 6.8 Angstrom resolution · ZK1 A1101 · binds GLU402, TYR405, TYR450, PRO478, LEU479, THR480, ARG485, GLY653 and 6 more
  • 5VHX · GluA2-1xGSG1L bound to ZK · ZK1 A1101 · binds TYR450, PRO478, LEU479, THR480, ARG485, GLY653, SER654, THR686 and 3 more
  • 5VHY · GluA2-2xGSG1L bound to ZK · ZK1 A1101 · binds TYR450, PRO478, LEU479, THR480, ARG485, GLY653, SER654, THR686 and 3 more
  • 6NJL · Architecture and subunit arrangement of native AMPA receptors · ZK1 A901 · binds GLU402, TYR450, PRO478, LEU479, THR480, ARG485, ALA652, GLY653 and 5 more
  • 6NJM · Architecture and subunit arrangement of native AMPA receptors · ZK1 A901 · binds GLU402, TYR405, TYR450, PRO478, LEU479, THR480, ARG485, SER652 and 7 more
  • 6UCB · GluA2 in complex with its auxiliary subunit CNIH3 - with antagonist ZK200775, LBD, TMD… · ZK1 A901 · binds GLU402, TYR405, TYR450, PRO478, THR480, ARG485, GLY653, SER654 and 3 more
  • 7LEP · The composite LBD-TMD structure combined from all hippocampal AMPAR subtypes at 3.25… · ZK1 A901 · binds TYR401, TYR446, PRO474, LEU475, THR476, ARG481, GLY649, SER650 and 4 more
  • 8AYM · Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118 · ZK1 C901 · binds GLU398, TYR401, TYR446, PRO474, LEU475, THR476, ARG481, GLY649 and 8 more

Residues it binds most

TYR 164, THR 164, GLU 149, SER 164, ARG 164, GLY 164, PRO 163, LEU 142, MET 137, ALA 6 (residue and the binding sites it lines).

Found with

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • CLR · Cholesterol
  • PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine
  • OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
  • XVD · 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol
  • C14 · Tetradecane
  • D10 · Decane
  • D12 · Dodecane
  • POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
  • SPD · Spermidine
  • BMA · beta-D-mannopyranose
  • OCT · N-octane

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