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Ligand · FWF

FWF · N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide

FWF, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide (C24 H36 N2 O4 S2, 480.7 g/mol), in the MolNFT structures on GenesisL1: bound in 26 records (13 PDB entries). Every binding site with its residues within 4.5 Å…

Component
FWF
Formula
C24 H36 N2 O4 S2
Class
ligand
Structures
26
PDB entries
13

Binding sites

FWF in 26 structures; the first of them:

  • 4U1O · GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form C · FWF A302 · binds ILE92, LYS104, PRO105, PHE106, MET107, SER108, SER217, LYS218 and 4 more
  • 4U1W · Full length GluA2-kainate-(R,R)-2b complex crystal form A · FWF A903 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 17 more
  • 4U1X · Full length GluA2-kainate-(R,R)-2b complex crystal form B · FWF B903 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 16 more
  • 4U1Y · Full length GluA2-FW-(R,R)-2b complex · FWF A2003 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 14 more
  • 4U1Z · GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form D · FWF A302 · binds ILE92, LYS104, PRO105, PHE106, MET107, SER108, SER217, LYS218 and 4 more
  • 4U21 · GluA2flip sLBD complexed with FW and (R,R)-2b crystal form E · FWF B402 · binds ILE92, LYS104, PRO105, PHE106, MET107, SER108, SER217, LYS218 and 16 more
  • 4U22 · GluA2flip sLBD complexed with FW and (R,R)-2b crystal form D · FWF A402 · binds ILE92, LYS104, PRO105, PHE106, MET107, SER108, SER217, LYS218 and 4 more
  • 4U23 · GluA2flip sLBD complexed with FW and (R,R)-2b crystal form F · FWF A402 · binds ILE92, LYS104, PRO105, PHE106, MET107, SER108, SER217, LYS218 and 4 more
  • 4U5B · Crystal structure of GluA2 A622T, con-ikot-ikot snail toxin, partial agonist KA and… · FWF B903 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 17 more
  • 4U5C · Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist FW and postitive… · FWF B903 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 15 more
  • 4U5D · Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist KA and postitive… · FWF A903 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 17 more
  • 4U5E · Crystal structure of GluA2 T625G, con-ikot-ikot snail toxin, partial agonist KA and… · FWF A903 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 16 more
  • 4U5F · Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist KA and postitive… · FWF B901 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 17 more
  • 4U1O · GLUA2FLIP slbd complexed with kainate and (R,R)-2B crystal form C · FWF A302 · binds ILE92, LYS104, PRO105, PHE106, MET107, SER108, SER217, LYS218 and 4 more
  • 4U1W · Full length GLUA2-kainate-(R,R)-2B complex crystal form a · FWF A903 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 17 more
  • 4U1X · Full length GLUA2-kainate-(R,R)-2B complex crystal form B · FWF B903 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 16 more
  • 4U1Y · Full length GLUA2-fw-(R,R)-2B complex · FWF A2003 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 14 more
  • 4U1Z · GLUA2FLIP slbd complexed with kainate and (R,R)-2B crystal form D · FWF A302 · binds ILE92, LYS104, PRO105, PHE106, MET107, SER108, SER217, LYS218 and 4 more
  • 4U21 · GLUA2FLIP slbd complexed with fw and (R,R)-2B crystal form E · FWF B402 · binds ILE92, LYS104, PRO105, PHE106, MET107, SER108, SER217, LYS218 and 16 more
  • 4U22 · GLUA2FLIP slbd complexed with fw and (R,R)-2B crystal form D · FWF A402 · binds ILE92, LYS104, PRO105, PHE106, MET107, SER108, SER217, LYS218 and 4 more
  • 4U23 · GLUA2FLIP slbd complexed with fw and (R,R)-2B crystal form F · FWF A402 · binds ILE92, LYS104, PRO105, PHE106, MET107, SER108, SER217, LYS218 and 4 more
  • 4U5B · Crystal structure of GLUA2 A622T, con-ikot-ikot snail toxin, partial agonist ka and… · FWF B903 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 17 more
  • 4U5C · Crystal structure of GLUA2, con-ikot-ikot snail toxin, partial agonist fw and postitive… · FWF B903 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 15 more
  • 4U5D · Crystal structure of GLUA2, con-ikot-ikot snail toxin, partial agonist ka and postitive… · FWF A903 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 17 more
  • 4U5E · Crystal structure of GLUA2 T625G, con-ikot-ikot snail toxin, partial agonist ka and… · FWF A903 · binds ILE481, LYS493, PRO494, PHE495, MET496, SER497, SER729, LYS730 and 16 more

Residues it binds most

SER 42, LYS 42, LEU 42, GLY 42, ILE 42, MET 42, PHE 42, PRO 42, VAL 38, GLU 2 (residue and the binding sites it lines).

Found with

  • KAI · 3-(carboxymethyl)-4-isopropenylproline
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • FWD · 2-amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid
  • MES · 2-(N-morpholino)-ethanesulfonic acid

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