MolNFT v1 · #107176 · protein

GLUA2FLIP slbd complexed with fw and (R,R)-2B crystal form D

4U22 · Glutamate receptor 2: “GLUA2FLIP slbd complexed with fw and (R,R)-2B crystal form D”. X-ray diffraction, 2 ligands (FWD, FWF), 2 pockets (best druggability 0.43). MolNFT v1 #107176 on GenesisL1: 3D structure, binding sites and…

PDB: 4U22
Type: protein
Length: 262 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamate receptor 2
UniProt: P19491
Ligands: FWD, FWF
Pockets: 2 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamate receptor 2	protein	262	37% helix, 21% strand	P19491

Ligands and binding sites

FWD · 2-amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid · ligand · chains A
FWF · N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	132	0.43	0.76	27	empty
2	106	0.41	0.77	18	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4U22 · GluA2flip sLBD complexed with FW and (R,R)-2b crystal form D · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19491
Elsewhere: RCSB PDB 4U22 · PDBe 4U22 · UniProt P19491

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