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Ligand · E2Q

E2Q · 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide

E2Q, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide (C12 H8 N4 O6 S, 336.3 g/mol), in the MolNFT structures on GenesisL1: bound in 11 records (6 PDB entries). Every binding site with its residues within 4.5 Å…

Component
E2Q
Formula
C12 H8 N4 O6 S
Class
ligand
Structures
11
PDB entries
6

Binding sites

E2Q in 11 structures; the first of them:

  • 6QKC · GluA1/2 In complex with auxiliary subunit gamma-8 · E2Q A901 · binds TYR446, PRO474, LEU475, THR476, ARG481, THR682, GLU701, THR703 and 2 more
  • 6QKZ · Full length GluA1/2-gamma8 complex · E2Q A901 · binds PRO474, LEU475, THR476
  • 7OCA · Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2 · E2Q A901 · binds GLU398, TYR446, PRO474, THR476, ARG481, SER650, THR682, GLU701 and 2 more
  • 7OCD · Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8… · E2Q A901 · binds GLU398, TYR446, PRO474, LEU475, THR476, ARG481, LEU646, THR682 and 3 more
  • 7OCE · Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) · E2Q A901 · binds GLU398, TYR446, PRO474, THR476, ARG481, SER650, THR682, GLU701 and 2 more
  • 6FQH · GLUA2(FLOP) S729C ligand binding core dimer bound to nbqx at 1.76 ångström resolution · E2Q A301 · binds GLU13, TYR16, TYR61, PRO89, LEU90, THR91, ARG96, LEU138 and 4 more
  • 6QKC · GLUA1/2 in complex with auxiliary subunit gamma-8 · E2Q A901 · binds TYR446, PRO474, LEU475, THR476, ARG481, THR682, GLU701, MET704 and 1 more
  • 6QKZ · Full length GLUA1/2-GAMMA8 complex · E2Q A901 · binds PRO474, LEU475, THR476
  • 7OCA · Resting state full-length GLUA1/A2 heterotertramer in complex with tarp gamma 8 and CNIH2 · E2Q A901 · binds TYR446, PRO474, THR476, ARG481, SER650, THR682, GLU701, MET704 and 1 more
  • 7OCD · Resting state GLUA1/A2 heterotetramer in complex with auxiliary subunit tarp gamma 8… · E2Q A901 · binds TYR446, PRO474, LEU475, THR476, ARG481, THR682, GLU701, MET704 and 1 more
  • 7OCE · Resting state GLUA1/A2 AMPA receptor in complex with tarp gamma 8 and CNIH2 (lbd-tmd) · E2Q A901 · binds TYR446, PRO474, THR476, ARG481, SER650, THR682, GLU701, MET704 and 1 more

Residues it binds most

THR 42, TYR 34, GLU 32, PRO 42, ARG 34, MET 34, LEU 26, SER 18 (residue and the binding sites it lines).

Found with

  • PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine
  • CLR · Cholesterol
  • BMA · beta-D-mannopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate

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