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Ligand · IWD

IWD · 2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid

IWD, 2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid (C7 H8 I N3 O4, 325.1 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
IWD
Formula
C7 H8 I N3 O4
Class
ligand
Structures
6
PDB entries
3

Binding sites

IWD in 6 structures; the first of them:

  • 1MQG · Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with… · IWD A301 · binds GLU13, TYR61, PRO89, LEU90, THR91, ARG96, LEU138, SER140 and 8 more
  • 1MY4 · crystal structure of glutamate receptor ligand-binding core in complex with… · IWD A601 · binds GLU13, TYR61, PRO89, LEU90, THR91, ARG96, LEU138, GLY141 and 7 more
  • 3T96 · Iodowillardiine bound to a double cysteine mutant (A452C/S652C) of the ligand binding… · IWD B601 · binds GLU13, TYR61, PRO89, LEU90, THR91, ARG96, LEU138, GLY141 and 8 more
  • 1MQG · Crystal structure of the GLUR2 ligand binding core (S1S2J) in complex with… · IWD A301 · binds GLU13, TYR61, PRO89, LEU90, THR91, ARG96, LEU138, SER140 and 8 more
  • 1MY4 · Crystal structure of glutamate receptor ligand-binding core in complex with… · IWD A601 · binds GLU13, TYR61, PRO89, LEU90, THR91, ARG96, LEU138, GLY141 and 7 more
  • 3T96 · Iodowillardiine bound to a double cysteine mutant (A452C/S652C) of the ligand binding… · IWD B601 · binds GLU13, TYR61, PRO89, LEU90, THR91, ARG96, LEU138, GLY141 and 8 more

Residues it binds most

LEU 16, THR 16, TYR 16, GLU 16, SER 16, ARG 16, GLY 16, MET 16, PRO 16 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • SO4 · Sulfate ion
  • GOL · Glycerol

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