MolNFT v2 · #180039 · protein + RNA
The cryo-EM structure of the human 17S U2 snRNP
7EVO: “The cryo-EM structure of the human 17S U2 snRNP”. Electron microscopy at 2.5, 2 ligands (9B0, ZN). MolNFT v2 #180039 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EVO
- Type
- protein + RNA
- Length
- 4,817 residues
- Chains
- 21
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.5
- Source
- Homo sapiens
- UniProt
- O75533, Q13435, Q15393, Q15427, Q9BWJ5, Q7RTV0, Q15459, Q15428, Q12874, O43719, A0A0C4DG89, P09661, P08579, P62316, P62306, P62304, P62308, P62318, P14678, P62314
- Ligands
- 9B0, ZN
Structure
electron microscopy · resolution 2.5 · 21 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | — | rna | 148 | — | — |
| 1 | — | protein | 815 | — | O75533 |
| 2 | — | protein | 182 | — | Q13435 |
| 3 | — | protein | 1180 | — | Q15393 |
| 4 | — | protein | 160 | — | Q15427 |
| 5 | — | protein | 66 | — | Q9BWJ5 |
| 6 | — | protein | 85 | — | Q7RTV0 |
| A | — | protein | 123 | — | Q15459 |
| B | — | protein | 100 | — | Q15428 |
| C | — | protein | 422 | — | Q12874 |
| D | — | protein | 200 | — | O43719 |
| E | — | protein | 455 | — | A0A0C4DG89 |
| F | — | protein | 162 | — | P09661 |
| G | — | protein | 166 | — | P08579 |
| a | — | protein | 90 | — | P62316 |
| b | — | protein | 74 | — | P62306 |
| c | — | protein | 79 | — | P62304 |
| d | — | protein | 74 | — | P62308 |
| e | — | protein | 83 | — | P62318 |
| f | — | protein | 71 | — | P14678 |
| g | — | protein | 82 | — | P62314 |
Ligands and binding sites
- 9B0 · [(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{R})-6-methyl-6-oxidanyl-7-[(2~{R}, 3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] 4-cycloheptylpiperazine-1-carboxylate · ligand · chains 1, 6
- ZN · Zinc ion · metal · 4 copies · chains 6, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7EVO · The cryo-EM structure of the human 17S U2 snrnp · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75533
- Every structure of UniProt Q13435
- Every structure of UniProt Q15393
- Every structure of UniProt Q15427
- Every structure of UniProt Q9BWJ5
- Every structure of UniProt Q7RTV0
- Every structure of UniProt Q15459
- Every structure of UniProt Q15428
- Every structure of UniProt Q12874
- Every structure of UniProt O43719
- Every structure of UniProt A0A0C4DG89
- Every structure of UniProt P09661
- Every structure of UniProt P08579
- Every structure of UniProt P62316
- Every structure of UniProt P62306
- Every structure of UniProt P62304
- Every structure of UniProt P62308
- Every structure of UniProt P62318
- Every structure of UniProt P14678
- Every structure of UniProt P62314
- Elsewhere: RCSB PDB 7EVO · PDBe 7EVO · UniProt O75533 · UniProt Q13435 · UniProt Q15393 · UniProt Q15427 · UniProt Q9BWJ5 · UniProt Q7RTV0 · UniProt Q15459 · UniProt Q15428 · UniProt Q12874 · UniProt O43719 · UniProt A0A0C4DG89 · UniProt P09661 · UniProt P08579 · UniProt P62316 · UniProt P62306 · UniProt P62304 · UniProt P62308 · UniProt P62318 · UniProt P14678 · UniProt P62314
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