UniProt Q15427
Splicing factor 3B subunit 4 (Q15427)
Splicing factor 3B subunit 4 (UniProt Q15427): 31 experimental structures and 1 predicted model on GenesisL1, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15427
- Protein
- Splicing factor 3B subunit 4
- Experimental structures
- 31
- Predicted models
- 1
- Pockets
- 6 · 5 records with a druggable one
Structures
32 records of Q15427 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1X5T | Solution structure of the second RRM domain in splicing factor = 3B | solution nmr | A | — | — |
| 1X5T | Solution structure of the second rrm domain in splicing factor = 3B | solution nmr | A | — | — |
| 5Z56 | cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | electron microscopy | 4 | — | — |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early bact) at 4.9 ångström. | electron microscopy | 4 | — | — |
| 6AH0 | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | electron microscopy | 4 | — | — |
| 6AH0 | The cryo-EM structure of the precusor of human pre-catalytic spliceosome (pre-B complex) | electron microscopy | 4 | — | — |
| 6AHD | The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution | electron microscopy | 4 | — | — |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | B4 | — | — |
| 6Y53 | human 17S U2 snRNP low resolution part | electron microscopy | o | — | 2 (best 0.71) |
| 6Y53 | Human 17S U2 snrnp low resolution part | electron microscopy | o | — | — |
| 6Y5Q | Human 17S U2 snrnp | electron microscopy | o | — | — |
| 7ABG | Human pre-Bact-1 spliceosome | electron microscopy | w | — | 1 (best 0.82) |
| 7ABH | Human pre-bact-2 spliceosome (SF3B/U2 snrnp portion) | electron microscopy | w | — | — |
| 7ABI | Human pre-bact-2 spliceosome | electron microscopy | w | — | — |
| 7DVQ | Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | electron microscopy | 4 | — | — |
| 7DVQ | Cryo-EM structure of the activated human minor spliceosome (minor bact complex) | electron microscopy | 4 | — | — |
| 7EVO | The cryo-EM structure of the human 17S U2 snRNP | electron microscopy | 4 | — | — |
| 7EVO | The cryo-EM structure of the human 17S U2 snrnp | electron microscopy | 4 | — | — |
| 7ONB | Structure of the U2 5' module of the A3'-ssa complex | electron microscopy | K | — | — |
| 7VPX | The cryo-EM structure of the human pre-A complex | electron microscopy | 4 | — | 1 (best 0.72) |
| 8CH6 | Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius… | electron microscopy | F | — | — |
| 8H6E | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | electron microscopy | 2J | — | — |
| 8H6K | Cryo-EM structure of human exon-defined spliceosome in the mature B state. | electron microscopy | 2J | — | — |
| 8HK1 | The cryo-EM structure of human pre-17S U2 snRNP | electron microscopy | 4 | — | 1 (best 0.73) |
| 8I0U | The cryo-EM structure of human Bact-IV complex | electron microscopy | 4 | — | — |
| 8I0V | The cryo-EM structure of human post-Bact complex | electron microscopy | 4 | — | — |
| 8QZS | Cryo-EM structure of the cross-exon B-like complex | electron microscopy | B4 | — | — |
| 8R08 | Cryo-EM structure of the cross-exon pre-B+AMPPNP complex | electron microscopy | B4 | — | — |
| 8R09 | Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex | electron microscopy | B4 | — | — |
| 8R0B | Cryo-EM structure of the cross-exon pre-B+ATP complex | electron microscopy | B4 | — | — |
| 8RM5 | Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex | electron microscopy | B4 | — | — |
| Q15427 | AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 4 (Q15427) | predicted | A | — | 1 (best 0.51) |
Experiment against prediction
- 8R09 chain B4 against the predicted model Q15427: TM-score 0.94, RMSD 0.83 Å
- 8QZS chain B4 against the predicted model Q15427: TM-score 0.94, RMSD 0.83 Å
- 8H6E chain 2J against the predicted model Q15427: TM-score 0.94, RMSD 0.82 Å
- 6AHD chain 4 against the predicted model Q15427: TM-score 0.94, RMSD 0.82 Å
- 8H6K chain 2J against the predicted model Q15427: TM-score 0.94, RMSD 0.82 Å
- 6AH0 chain 4 against the predicted model Q15427: TM-score 0.94, RMSD 0.82 Å
- 6AH0 chain 4 against the predicted model Q15427: TM-score 0.94, RMSD 0.82 Å
- 8R0B chain B4 against the predicted model Q15427: TM-score 0.94, RMSD 0.84 Å
- 8R08 chain B4 against the predicted model Q15427: TM-score 0.94, RMSD 0.85 Å
- 8RM5 chain B4 against the predicted model Q15427: TM-score 0.94, RMSD 0.85 Å
Elsewhere
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