UniProt Q15428
Splicing factor 3A subunit 2 (Q15428)
Splicing factor 3A subunit 2 (UniProt Q15428): 30 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15428
- Protein
- Splicing factor 3A subunit 2
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 17 · 7 records with a druggable one
Structures
31 records of Q15428 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5Z56 | cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | electron microscopy | v | ZN | 1 (best 0.83) |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early bact) at 4.9 ångström. | electron microscopy | v | — | — |
| 6AH0 | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | electron microscopy | v | — | — |
| 6AH0 | The cryo-EM structure of the precusor of human pre-catalytic spliceosome (pre-B complex) | electron microscopy | v | — | — |
| 6FF4 | human Bact spliceosome core structure | electron microscopy | 7 | MG | 4 (best 0.88) |
| 6FF4 | Human bact spliceosome core structure | electron microscopy | 7 | — | — |
| 6FF7 | Human bact spliceosome core structure | electron microscopy | 7 | — | — |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | A2 | ZN | — |
| 6Y53 | human 17S U2 snRNP low resolution part | electron microscopy | 7 | — | 1 (best 0.59) |
| 6Y53 | Human 17S U2 snrnp low resolution part | electron microscopy | 7 | — | — |
| 6Y5Q | Human 17S U2 snrnp | electron microscopy | 7 | — | — |
| 7ABG | Human pre-Bact-1 spliceosome | electron microscopy | F | — | — |
| 7ABH | Human pre-bact-2 spliceosome (SF3B/U2 snrnp portion) | electron microscopy | F | — | — |
| 7ABI | Human pre-bact-2 spliceosome | electron microscopy | F | — | — |
| 7EVO | The cryo-EM structure of the human 17S U2 snRNP | electron microscopy | B | — | — |
| 7EVO | The cryo-EM structure of the human 17S U2 snrnp | electron microscopy | B | — | — |
| 7ONB | Structure of the U2 5' module of the A3'-ssa complex | electron microscopy | M | ZN | — |
| 7Q4O | Substrate-bound A-like U2 snRNP | electron microscopy | 1 | ZN | 2 (best 0.68) |
| 7Q4O | Substrate-bound a-like U2 snrnp | electron microscopy | 1 | ZN | — |
| 7Q4P | U2 snRNP after ATP-dependent remodelling | electron microscopy | 1 | ZN | 3 (best 0.69) |
| 7Q4P | U2 snrnp after ATP-dependent remodelling | electron microscopy | 1 | ZN | — |
| 7VPX | The cryo-EM structure of the human pre-A complex | electron microscopy | B | ZN | 2 (best 0.80) |
| 8CH6 | Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius… | electron microscopy | I | ZN | 3 (best 0.90) |
| 8H6E | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | electron microscopy | 2E | — | — |
| 8H6K | Cryo-EM structure of human exon-defined spliceosome in the mature B state. | electron microscopy | 2E | — | — |
| 8HK1 | The cryo-EM structure of human pre-17S U2 snRNP | electron microscopy | B | — | — |
| 8QZS | Cryo-EM structure of the cross-exon B-like complex | electron microscopy | 8 | — | — |
| 8R09 | Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex | electron microscopy | 8 | — | — |
| 8R0B | Cryo-EM structure of the cross-exon pre-B+ATP complex | electron microscopy | 8 | — | — |
| 8RM5 | Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex | electron microscopy | 8 | — | — |
| Q15428 | AlphaFold monomer V2.0 prediction for splicing factor 3A subunit 2 (Q15428) | predicted | A | — | 1 (best 0.31) |
Ligands
Experiment against prediction
- 7Q4P chain 1 against the predicted model Q15428: TM-score 0.93, RMSD 0.50 Å
- 7Q4P chain 1 against the predicted model Q15428: TM-score 0.93, RMSD 0.50 Å
- 7ONB chain M against the predicted model Q15428: TM-score 0.92, RMSD 0.65 Å
- 7Q4O chain 1 against the predicted model Q15428: TM-score 0.92, RMSD 0.57 Å
- 7Q4O chain 1 against the predicted model Q15428: TM-score 0.92, RMSD 0.57 Å
- 6QX9 chain A2 against the predicted model Q15428: TM-score 0.78, RMSD 2.57 Å
- 7EVO chain B against the predicted model Q15428: TM-score 0.76, RMSD 2.21 Å
- 7EVO chain B against the predicted model Q15428: TM-score 0.76, RMSD 2.21 Å
- 8HK1 chain B against the predicted model Q15428: TM-score 0.76, RMSD 2.21 Å
- 6Y53 chain 7 against the predicted model Q15428: TM-score 0.76, RMSD 2.21 Å
Elsewhere
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