UniProt Q15459
Splicing factor 3A subunit 1 (Q15459)
Splicing factor 3A subunit 1 (UniProt Q15459): 36 experimental structures and 1 predicted model on GenesisL1, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15459
- Protein
- Splicing factor 3A subunit 1
- Experimental structures
- 36
- Predicted models
- 1
- Pockets
- 9 · 7 records with a druggable one
Structures
37 records of Q15459 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZKH | Solution structure of a human ubiquitin-like domain in SF3A1 | solution nmr | A | — | — |
| 1ZKH | Solution structure of a human ubiquitin-like domain in SF3A1 | solution nmr | A | — | — |
| 2DT6 | Solution structure of the first SURP domain of human splicing factor SF3a120 | solution nmr | A | — | — |
| 2DT6 | Solution structure of the first surp domain of human splicing factor SF3A120 | solution nmr | A | — | — |
| 2DT7 | Solution structure of the second SURP domain of human splicing factor SF3a120 in complex with a… | solution nmr | B | — | — |
| 2DT7 | Solution structure of the second surp domain of human splicing factor SF3A120 in complex with a… | solution nmr | B | — | — |
| 5Z56 | cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | electron microscopy | u | — | — |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early bact) at 4.9 ångström. | electron microscopy | u | — | — |
| 6AH0 | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | electron microscopy | u | — | — |
| 6AH0 | The cryo-EM structure of the precusor of human pre-catalytic spliceosome (pre-B complex) | electron microscopy | u | — | — |
| 6AHD | The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution | electron microscopy | u | — | — |
| 6FF7 | Human bact spliceosome core structure | electron microscopy | p | — | — |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | A1 | — | — |
| 6Y53 | human 17S U2 snRNP low resolution part | electron microscopy | 6 | — | 1 (best 0.59) |
| 6Y53 | Human 17S U2 snrnp low resolution part | electron microscopy | 6 | — | — |
| 6Y5Q | Human 17S U2 snrnp | electron microscopy | 6 | — | — |
| 7ABG | Human pre-Bact-1 spliceosome | electron microscopy | p | — | — |
| 7ABI | Human pre-bact-2 spliceosome | electron microscopy | p | — | — |
| 7EVO | The cryo-EM structure of the human 17S U2 snRNP | electron microscopy | A | — | — |
| 7EVO | The cryo-EM structure of the human 17S U2 snrnp | electron microscopy | A | — | — |
| 7P0V | Crystal structure of human SF3A1 ubiquitin-like domain in complex with U1 snRNA stem-loop 4 | x-ray diffraction | A | — | 2 (best 0.54) |
| 7P0V | Crystal structure of human SF3A1 ubiquitin-like domain in complex with U1 snrna stem-loop 4 | x-ray diffraction | A | — | — |
| 7VH9 | Solution structure of the chimeric peptide of the first SURP domain of Human SF3A1 and the… | solution nmr | A | — | — |
| 7VPX | The cryo-EM structure of the human pre-A complex | electron microscopy | A | — | — |
| 8CH6 | Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius… | electron microscopy | H | — | — |
| 8H6E | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | electron microscopy | 2D | — | — |
| 8H6K | Cryo-EM structure of human exon-defined spliceosome in the mature B state. | electron microscopy | 2D | — | — |
| 8HK1 | The cryo-EM structure of human pre-17S U2 snRNP | electron microscopy | A | — | — |
| 8Q7N | cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) | electron microscopy | 7 | — | 1 (best 0.76) |
| 8QPE | Cryo-EM Structure of Pre-B-like Complex (core part) | electron microscopy | 7 | — | 1 (best 0.75) |
| 8QPK | Cryo-EM Structure of Pre-B+5'ss Complex (core part) | electron microscopy | 7 | — | 1 (best 0.83) |
| 8QZS | Cryo-EM structure of the cross-exon B-like complex | electron microscopy | 7 | — | 1 (best 0.83) |
| 8R08 | Cryo-EM structure of the cross-exon pre-B+AMPPNP complex | electron microscopy | 7 | — | — |
| 8R09 | Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex | electron microscopy | 7 | — | — |
| 8R0B | Cryo-EM structure of the cross-exon pre-B+ATP complex | electron microscopy | 7 | — | — |
| 8RM5 | Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex | electron microscopy | 7 | — | 1 (best 0.83) |
| Q15459 | AlphaFold monomer V2.0 prediction for splicing factor 3A subunit 1 (Q15459) | predicted | A | — | 1 (best 0.39) |
Experiment against prediction
- 7P0V chain A against the predicted model Q15459: TM-score 0.95, RMSD 1.02 Å
- 7P0V chain A against the predicted model Q15459: TM-score 0.95, RMSD 1.02 Å
- 1ZKH chain A against the predicted model Q15459: TM-score 0.89, RMSD 1.51 Å
- 1ZKH chain A against the predicted model Q15459: TM-score 0.89, RMSD 1.51 Å
- 2DT6 chain A against the predicted model Q15459: TM-score 0.88, RMSD 1.16 Å
- 2DT6 chain A against the predicted model Q15459: TM-score 0.88, RMSD 1.16 Å
- 8HK1 chain A against the predicted model Q15459: TM-score 0.81, RMSD 2.16 Å
- 7VPX chain A against the predicted model Q15459: TM-score 0.81, RMSD 2.16 Å
- 7EVO chain A against the predicted model Q15459: TM-score 0.81, RMSD 2.16 Å
- 7EVO chain A against the predicted model Q15459: TM-score 0.81, RMSD 2.16 Å
Elsewhere
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