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MolNFT v2 · #153279 · protein + RNA

Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution

6ID0: “Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom…”. Electron microscopy at 2.9, 4 ligands (IHP, GTP, MG). MolNFT v2 #153279 on GenesisL1: 3D structure, binding sites and…

PDB
6ID0
Type
protein + RNA
Length
10,794 residues
Chains
42
Method
electron microscopy
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
2.9
Source
Homo sapiens
UniProt
Q6P2Q9, Q15029, Q96DI7, Q9BZJ0, Q99459, O95926, P41223, Q9NW64, Q9P013, Q13573, Q9Y3C6, O43660, O60508, Q2TBE0, Q9HCS7, P62318, Q66K91, P62314, P62316, P62306, P62304, P62308, Q9UMS4, O75934, P09661, P08579, O60306, Q9UNP9
Ligands
IHP, GTP, MG, ZN

Structure

electron microscopy · resolution 2.9 · 37 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein1981—Q6P2Q9
B—rna98——
C—protein888—Q15029
E—protein303—Q96DI7
F—rna97——
J—protein556—Q9BZJ0
L—protein475—Q99459
M—protein130—O95926
N—protein143—P41223
O—protein290—Q9NW64
P—protein118—Q9P013
R—protein272—Q13573
S—protein159—Q9Y3C6
T—protein317—O43660
W—protein509—O60508
G—rna70——
H—rna140——
U—protein347—Q2TBE0
I—protein568—Q9HCS7
a, h—protein81—P62318
b, i—protein86—Q66K91
c, j—protein82—P62314
d—protein97—P62316
f, m—protein74—P62306
e, l—protein79—P62304
g—protein74—P62308
q—protein132—Q9UMS4
r—protein131—Q9UMS4
s—protein67—Q9UMS4
t—protein67—Q9UMS4
K—protein152—O75934
k—protein85—P62316
n—protein67—P62308
o—protein162—P09661
p—protein94—P08579
Q—protein1322—O60306
y—protein79—Q9UNP9

Ligands and binding sites

  • IHP · Inositol hexakisphosphate · ligand · chains A
  • GTP · Guanosine-5'-triphosphate · ligand · chains A, C
  • MG · Magnesium ion · metal · 7 copies · chains C, F, A
  • ZN · Zinc ion · metal · 7 copies · chains N, O, U

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 6ID0 · Cryo-EM structure of a human intron lariat spliceosome prior to PRP43 loaded (ILS1… · the same entry in another collection · chain K against K, TM-score 1.00

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