UniProt O43660
Pleiotropic regulator 1 (O43660)
Pleiotropic regulator 1 (UniProt O43660): 23 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 16 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43660
- Protein
- Pleiotropic regulator 1
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 16 · 5 records with a druggable one
Structures
24 records of O43660 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4YVD | Crytsal structure of human Pleiotropic Regulator 1 (PRL1) | x-ray diffraction | A | — | — |
| 4YVD | Crytsal structure of human pleiotropic regulator 1 (PRL1) | x-ray diffraction | A | — | — |
| 5MQF | Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex) | electron microscopy | D | — | — |
| 5XJC | Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | electron microscopy | T | — | — |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early bact) at 4.9 ångström. | electron microscopy | T | — | — |
| 6FF4 | human Bact spliceosome core structure | electron microscopy | D | — | 2 (best 0.86) |
| 6FF4 | Human bact spliceosome core structure | electron microscopy | D | — | — |
| 6FF7 | Human bact spliceosome core structure | electron microscopy | D | — | — |
| 6ICZ | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 ångström | electron microscopy | T | — | — |
| 6ID0 | Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9… | electron microscopy | T | — | — |
| 6ID0 | Cryo-EM structure of a human intron lariat spliceosome prior to PRP43 loaded (ILS1 complex) at 2.9… | electron microscopy | T | — | — |
| 6ID1 | Cryo-EM structure of a human intron lariat spliceosome after PRP43 loaded (ILS2 complex) at 2.9… | electron microscopy | T | — | — |
| 6ZYM | Human C Complex Spliceosome - High-resolution CORE | electron microscopy | D | — | 4 (best 0.85) |
| 6ZYM | Human C complex spliceosome - high-resolution core | electron microscopy | D | — | — |
| 7AAV | Human pre-bact-2 spliceosome core structure | electron microscopy | G | — | — |
| 7ABI | Human pre-bact-2 spliceosome | electron microscopy | G | — | — |
| 7DH6 | Crystal structure of PLRG1 | x-ray diffraction | A, B, C, D | NI, SO4, CA | — |
| 7DVQ | Cryo-EM structure of the activated human minor spliceosome (minor bact complex) | electron microscopy | T | — | — |
| 7W59 | The cryo-EM structure of human pre-C*-I complex | electron microscopy | T | — | — |
| 7W5A | The cryo-EM structure of human pre-C*-II complex | electron microscopy | T | — | — |
| 7W5A | The cryo-EM structure of human pre-C*-II complex | electron microscopy | T | — | — |
| 8C6J | Human spliceosomal PM5 C* complex | electron microscopy | J | — | 4 (best 0.91) |
| 8I0U | The cryo-EM structure of human Bact-IV complex | electron microscopy | T | — | 4 (best 0.88) |
| O43660 | AlphaFold monomer V2.0 prediction for pleiotropic regulator 1 (O43660) | predicted | A | — | 2 (best 0.79) |
Ligands
Experiment against prediction
- 7DVQ chain T against the predicted model O43660: TM-score 0.99, RMSD 0.50 Å
- 8I0U chain T against the predicted model O43660: TM-score 0.99, RMSD 0.52 Å
- 6ZYM chain D against the predicted model O43660: TM-score 0.99, RMSD 0.51 Å
- 6ZYM chain D against the predicted model O43660: TM-score 0.99, RMSD 0.51 Å
- 6ID1 chain T against the predicted model O43660: TM-score 0.99, RMSD 0.60 Å
- 7DH6 chain C against the predicted model O43660: TM-score 0.99, RMSD 0.56 Å
- 7W5A chain T against the predicted model O43660: TM-score 0.99, RMSD 0.58 Å
- 7W5A chain T against the predicted model O43660: TM-score 0.99, RMSD 0.58 Å
- 6ID0 chain T against the predicted model O43660: TM-score 0.99, RMSD 0.64 Å
- 6ID0 chain T against the predicted model O43660: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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