MolNFT v1 · #176274 · protein

Crystal structure of PLRG1

7DH6 · Pleiotropic regulator 1: “Crystal structure of PLRG1”. X-ray diffraction, 3 ligands (CA, NI, SO4), 10 pockets (best druggability 0.85). MolNFT v1 #176274 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7DH6
Type: protein
Length: 1,160 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pleiotropic regulator 1
UniProt: O43660
Ligands: CA, NI, SO4
Pockets: 10 · best druggability 0.85

Structure

x-ray diffraction · 4 distinct chains · 0% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pleiotropic regulator 1	protein	283	0% helix, 52% strand	O43660
B	Pleiotropic regulator 1	protein	294	0% helix, 53% strand	O43660
C	Pleiotropic regulator 1	protein	292	0% helix, 53% strand	O43660
D	Pleiotropic regulator 1	protein	291	0% helix, 54% strand	O43660

Ligands and binding sites

CA · Calcium ion · metal · 3 copies · chains B, C, D
NI · Nickel (II) ion · metal · 2 copies · chains A, C
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	619	0.85	0.90	56	empty
2	1124	0.81	0.82	78	empty
3	338	0.80	0.90	54	empty
4	1181	0.80	0.81	86	empty
5	233	0.51	0.76	35	empty

Interfaces

4 interfaces between chains.

B–C · 693 Å² buried · 7 hydrogen bonds · protein-protein
A–D · 651 Å² buried · 5 hydrogen bonds · protein-protein
C–D · 174 Å² buried · 1 hydrogen bond · protein-protein
A–B · 163 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7DH6 · Crystal structure of PLRG1 · the same entry in another collection · chain D against D, TM-score 1.00
O43660 · AlphaFold monomer V2.0 prediction for pleiotropic regulator 1 (O43660) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43660
Elsewhere: RCSB PDB 7DH6 · PDBe 7DH6 · UniProt O43660

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.