UniProt Q9UMS4
Pre-mRNA-processing factor 19 (Q9UMS4)
Pre-mRNA-processing factor 19 (UniProt Q9UMS4), EC 2.3.2.27: 16 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UMS4
- Protein
- Pre-mRNA-processing factor 19
- EC
- 2.3.2.27
- Experimental structures
- 16
- Predicted models
- 1
- Pockets
- 3 · 1 record with a druggable one
Structures
17 records of Q9UMS4 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4LG8 | Crystal structure of PRPF19 WD40 repeats | x-ray diffraction | A | — | — |
| 4LG8 | Crystal structure of PRPF19 WD40 repeats | x-ray diffraction | A | — | — |
| 5MQF | Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex) | electron microscopy | G, H, I, J | — | — |
| 5XJC | Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | electron microscopy | q, r, s, t | — | — |
| 6FF7 | Human bact spliceosome core structure | electron microscopy | G, H, I, J | — | — |
| 6ICZ | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 ångström | electron microscopy | q, r, s, t | — | — |
| 6ID0 | Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9… | electron microscopy | q, r, s, t | — | — |
| 6ID0 | Cryo-EM structure of a human intron lariat spliceosome prior to PRP43 loaded (ILS1 complex) at 2.9… | electron microscopy | q, r, s, t | — | — |
| 6ID1 | Cryo-EM structure of a human intron lariat spliceosome after PRP43 loaded (ILS2 complex) at 2.9… | electron microscopy | q, r, s, t | — | — |
| 7A5P | Human C Complex Spliceosome - Medium-resolution PERIPHERY | electron microscopy | G, H, I, J | — | — |
| 7A5P | Human C complex spliceosome - medium-resolution periphery | electron microscopy | G, H, I, J | — | — |
| 7W59 | The cryo-EM structure of human pre-C*-I complex | electron microscopy | q, r, s, t | — | — |
| 7W5A | The cryo-EM structure of human pre-C*-II complex | electron microscopy | q, r, s, t | — | — |
| 7W5A | The cryo-EM structure of human pre-C*-II complex | electron microscopy | q, r, s, t | — | — |
| 8C6J | Human spliceosomal PM5 C* complex | electron microscopy | t, u, v, w | — | — |
| 8I0U | The cryo-EM structure of human Bact-IV complex | electron microscopy | q, r, s, t | — | — |
| Q9UMS4 | AlphaFold monomer V2.0 prediction for pre-mRNA-processing factor 19 (Q9UMS4) | predicted | A | — | 3 (best 0.80) |
Experiment against prediction
- 4LG8 chain A against the predicted model Q9UMS4: TM-score 0.99, RMSD 0.56 Å
- 4LG8 chain A against the predicted model Q9UMS4: TM-score 0.99, RMSD 0.56 Å
- 6ICZ chain t against the predicted model Q9UMS4: TM-score 0.82, RMSD 1.59 Å
- 6ID0 chain t against the predicted model Q9UMS4: TM-score 0.82, RMSD 1.59 Å
- 6ID0 chain t against the predicted model Q9UMS4: TM-score 0.82, RMSD 1.59 Å
- 6ID1 chain t against the predicted model Q9UMS4: TM-score 0.82, RMSD 1.59 Å
- 8C6J chain u against the predicted model Q9UMS4: TM-score 0.81, RMSD 2.40 Å
- 8I0U chain r against the predicted model Q9UMS4: TM-score 0.79, RMSD 2.75 Å
- 7W59 chain r against the predicted model Q9UMS4: TM-score 0.79, RMSD 2.75 Å
- 7W5A chain r against the predicted model Q9UMS4: TM-score 0.79, RMSD 2.75 Å
Elsewhere
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