MolNFT v1 · #176594 · protein
Bovine 20S immunoproteasome in complex with two human PA28ALPHA-beta activators
7DRW · Proteasome subunit alpha type-6: “Bovine 20S immunoproteasome in complex with two human PA28ALPHA-beta activators”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #176594 on GenesisL1: 3D structure, binding…
- PDB
- 7DRW
- Type
- protein
- Length
- 9,108 residues
- Chains
- 42
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome subunit alpha type-6; Proteasome subunit alpha type-2; Proteasome subunit…
- EC
- 3.4.25.1
- UniProt
- Q2YDE4, Q3T0Y5, Q3ZCK9, Q3ZBG0, Q5E987, Q3T0X5, Q58DU5, Q9UL46, Q06323, P33672, Q5E9K0, Q2TBX6, Q3T108, Q3SZC2, Q3T0T1, Q3T112
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 27 distinct chains · 45% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proteasome subunit alpha type-6 | protein | 235 | 38% helix, 23% strand | Q2YDE4 |
| B | Proteasome subunit alpha type-2 | protein | 226 | 35% helix, 27% strand | Q3T0Y5 |
| C | Proteasome subunit alpha type-4 | protein | 245 | 36% helix, 25% strand | Q3ZCK9 |
| D, P | Proteasome subunit alpha type-7 | protein | 232 | 37% helix, 23% strand | Q3ZBG0 |
| E, R | Proteasome subunit alpha type-5 | protein | 234 | 34% helix, 22% strand | Q5E987 |
| F, b | Proteasome subunit alpha type-1 | protein | 235 | 34% helix, 26% strand | Q3T0X5 |
| G, d | Proteasome subunit alpha type-3 | protein | 240 | 35% helix, 25% strand | Q58DU5 |
| H, O | Proteasome activator complex subunit 2 | protein | 209 | 75% helix, 1% strand | Q9UL46 |
| I, Q | Proteasome activator complex subunit 1 | protein | 213 | 76% helix, 1% strand | Q06323 |
| J, a | Proteasome activator complex subunit 1 | protein | 206 | 75% helix, 1% strand | Q06323 |
| K | Proteasome activator complex subunit 2 | protein | 207 | 74% helix, 0% strand | Q9UL46 |
| L, e | Proteasome activator complex subunit 1 | protein | 207 | 70% helix, 0% strand | Q06323 |
| M, g | Proteasome activator complex subunit 2 | protein | 209 | 72% helix, 0% strand | Q9UL46 |
| N, i | Proteasome activator complex subunit 1 | protein | 205 | 73% helix, 1% strand | Q06323 |
| c | Proteasome activator complex subunit 2 | protein | 205 | 75% helix, 0% strand | Q9UL46 |
| f | Proteasome subunit alpha type-6 | protein | 237 | 40% helix, 23% strand | Q2YDE4 |
| h | Proteasome subunit alpha type-2 | protein | 228 | 34% helix, 27% strand | Q3T0Y5 |
| j | Proteasome subunit alpha type-4 | protein | 246 | 37% helix, 25% strand | Q3ZCK9 |
| k, S | Proteasome subunit beta type-3 (EC 3.4.25.1) | protein | 204 | 30% helix, 27% strand | P33672 |
| l | Proteasome subunit beta type-2 (EC 3.4.25.1) | protein | 198 | 32% helix, 32% strand | Q5E9K0 |
| m, U | Proteasome subunit beta type-1 (EC 3.4.25.1) | protein | 213 | 30% helix, 30% strand | Q2TBX6 |
| n | Proteasome subunit beta type-4 (EC 3.4.25.1) | protein | 216 | 33% helix, 29% strand | Q3T108 |
| T | Proteasome subunit beta type-2 (EC 3.4.25.1) | protein | 197 | 32% helix, 32% strand | Q5E9K0 |
| V | Proteasome subunit beta type-4 (EC 3.4.25.1) | protein | 216 | 34% helix, 29% strand | Q3T108 |
| W, Z | Proteasome subunit beta type-9 (EC 3.4.25.1) | protein | 199 | 34% helix, 30% strand | Q3SZC2 |
| X, 1 | Proteasome subunit beta type-10 (EC 3.4.25.1) | protein | 219 | 29% helix, 34% strand | Q3T0T1 |
| Y, 2 | Proteasome subunit beta type-8 (EC 3.4.25.1) | protein | 201 | 34% helix, 29% strand | Q3T112 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 744 | 0.86 | 0.89 | 120 | empty |
| 2 | 864 | 0.85 | 0.87 | 112 | empty |
| 3 | 976 | 0.84 | 0.86 | 128 | empty |
| 4 | 592 | 0.84 | 0.89 | 96 | empty |
| 5 | 652 | 0.83 | 0.87 | 72 | empty |
Interfaces
137 interfaces between chains.
- a–i · 2294 Ų buried · 30 hydrogen bonds · protein-protein
- O–Q · 2117 Ų buried · 17 hydrogen bonds · protein-protein
- H–I · 2113 Ų buried · 16 hydrogen bonds · protein-protein
- M–N · 2075 Ų buried · 21 hydrogen bonds · protein-protein
- e–g · 2074 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 7DRW · Bovine 20S immunoproteasome in complex with two human PA28alpha-beta activators · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2YDE4
- Every structure of UniProt Q3T0Y5
- Every structure of UniProt Q3ZCK9
- Every structure of UniProt Q3ZBG0
- Every structure of UniProt Q5E987
- Every structure of UniProt Q3T0X5
- Every structure of UniProt Q58DU5
- Every structure of UniProt Q9UL46
- Every structure of UniProt Q06323
- Every structure of UniProt P33672
- Every structure of UniProt Q5E9K0
- Every structure of UniProt Q2TBX6
- Every structure of UniProt Q3T108
- Every structure of UniProt Q3SZC2
- Every structure of UniProt Q3T0T1
- Every structure of UniProt Q3T112
- Elsewhere: RCSB PDB 7DRW · PDBe 7DRW · UniProt Q2YDE4 · UniProt Q3T0Y5 · UniProt Q3ZCK9 · UniProt Q3ZBG0 · UniProt Q5E987 · UniProt Q3T0X5 · UniProt Q58DU5 · UniProt Q9UL46 · UniProt Q06323 · UniProt P33672 · UniProt Q5E9K0 · UniProt Q2TBX6 · UniProt Q3T108 · UniProt Q3SZC2 · UniProt Q3T0T1 · UniProt Q3T112
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