UniProt Q14416
Metabotropic glutamate receptor 2 (Q14416)
Metabotropic glutamate receptor 2 (UniProt Q14416), EC 5.2.1.8: 36 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 199 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q14416
- Protein
- Metabotropic glutamate receptor 2
- EC
- 5.2.1.8
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 199 · 19 records with a druggable one
Structures
37 records of Q14416 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4XAQ | mGluR2 ECD and mGluR3 ECD with ligands | x-ray diffraction | A, B | — | — |
| 4XAQ | MGLUR2 ecd and MGLUR3 ecd with ligands | x-ray diffraction | A, B | — | — |
| 4XAS | mGluR2 ECD ligand complex | x-ray diffraction | A, B | 40H | 10 (best 0.83) |
| 4XAS | MGLUR2 ecd ligand complex | x-ray diffraction | A, B | — | — |
| 5CNI | MGLU2 with glutamate | x-ray diffraction | A, B | — | — |
| 5CNJ | MGLUR2 with glutamate analog | x-ray diffraction | A, B | — | — |
| 5KZN | Metabotropic Glutamate Receptor | x-ray diffraction | A | NAG, MG | — |
| 5KZN | Metabotropic glutamate receptor | x-ray diffraction | A | NAG, MG | — |
| 5KZQ | Metabotropic Glutamate Receptor in complex with antagonist… | x-ray diffraction | A | 6YS, NAG | 4 (best 0.58) |
| 5KZQ | Metabotropic glutamate receptor in complex with antagonist (1~{S}… | x-ray diffraction | A | 6YS, NAG | — |
| 7E9G | Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu2 | electron microscopy | R, S | 40F, HZR | 14 (best 0.88) |
| 7E9G | Cryo-EM structure of gi-bound metabotropic glutamate receptor MGLU2 | electron microscopy | R, S | 40F, HZR | — |
| 7EPA | Cryo-EM structure of inactive mGlu2 homodimer | electron microscopy | A, B | — | 18 (best 0.83) |
| 7EPA | Cryo-EM structure of inactive MGLU2 homodimer | electron microscopy | A, B | — | — |
| 7EPB | Cryo-EM structure of LY354740-bound mGlu2 homodimer | electron microscopy | A, B | 40F | 20 (best 0.87) |
| 7EPB | Cryo-EM structure of LY354740-bound MGLU2 homodimer | electron microscopy | A, B | 40F | — |
| 7EPD | Cryo-EM structure of inactive mGlu2-7 heterodimer | electron microscopy | A | — | — |
| 7EPD | Cryo-EM structure of inactive MGLU2-7 heterodimer | electron microscopy | A | — | — |
| 7MTQ | CryoEM Structure of Full-Length mGlu2 in Inactive-State Bound to Antagonist LY341495 | electron microscopy | A, B | NAG, Z99 | 13 (best 0.84) |
| 7MTQ | Cryoem structure of full-length MGLU2 in inactive-state bound to antagonist LY341495 | electron microscopy | A, B | NAG, Z99 | — |
| 7MTR | CryoEM Structure of Full-Length mGlu2 Bound to Ago-PAM ADX55164 and Glutamate | electron microscopy | B, A | NAG, ZQY | — |
| 7MTR | Cryoem structure of full-length MGLU2 bound to ago-pam ADX55164 and glutamate | electron microscopy | B, A | NAG, ZQY | — |
| 7MTS | CryoEM Structure of mGlu2 - Gi Complex | electron microscopy | A, B | ZQY, GLU, NAG | 15 (best 0.83) |
| 7MTS | Cryoem structure of MGLU2 - gi complex | electron microscopy | A, B | ZQY, NAG | — |
| 8JCU | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode I) | electron microscopy | 2 | Z99, NAG | 9 (best 0.84) |
| 8JCX | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode… | electron microscopy | 2 | NAG, Z99 | 9 (best 0.80) |
| 8JCZ | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495, NAM563, and LY2389575… | electron microscopy | 2 | NAG, Z99 | 7 (best 0.86) |
| 8JD1 | Cryo-EM structure of mGlu2-mGlu3 heterodimer in Rco state | electron microscopy | 2 | GLU, CLR | 8 (best 0.82) |
| 8JD2 | Cryo-EM structure of G protein-free mGlu2-mGlu3 heterodimer in Acc state | electron microscopy | 2 | GLU, NAG | 8 (best 0.82) |
| 8JD3 | Cryo-EM structure of Gi1-bound mGlu2-mGlu3 heterodimer | electron microscopy | 2 | HZR, GLU, CLR, PEF | 8 (best 0.81) |
| 8JD4 | Cryo-EM structure of G protein-free mGlu2-mGlu4 heterodimer in Acc state | electron microscopy | 2 | NAG, GLU | 11 (best 0.81) |
| 8JD5 | Cryo-EM structure of Gi1-bound mGlu2-mGlu4 heterodimer | electron microscopy | 2 | HZR, GLU, CLR, PEF, NAG, BQI | 9 (best 0.80) |
| 8WG9 | mGlu2-mGlu4 heterodimer bound mGlu4 agonist E7P | electron microscopy | C | — | 11 (best 0.76) |
| 8WGB | mGlu2-4 heterodimer bound with Gi | electron microscopy | B | GLU | 12 (best 0.81) |
| 8WGC | heterodimer of mGlu2 and mGlu4 bound with mGlu2 agonist LY379268 | electron microscopy | D | W92 | 7 (best 0.70) |
| 8WGD | mGlu2-4 inactive heterodimer | electron microscopy | C | WAG | 6 (best 0.74) |
| Q14416 | AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 2 (Q14416) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 16 records
- GLU · Glutamic acid · in 7 records
- Z99 · 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine · in 5 records
- 40F · (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid · in 4 records
- HZR · 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one · in 4 records
- ZQY · 2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl) methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine · in 4 records
- CLR · Cholesterol · in 3 records
- 6YS · (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid · in 2 records
- MG · Magnesium ion · in 2 records
- PEF · Di-palmitoyl-3-sn-phosphatidylethanolamine · in 2 records
- 40H · (1R,4S,5S,6S)-4-aminospiro[bicyclo[3.1.0]hexane-2,1'-cyclopropane]-4,6-dicarboxylic acid · in 1 record
- BQI · 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine · in 1 record
- W92 · (1R,4R,5S,6R)-4-azanyl-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid · in 1 record
- WAG · (1S,2R)-2-[(2S)-2-azanyl-1-oxidanyl-1-oxidanylidene-3-(9H-xanthen-9-yl)propan-2-yl]cyclopropane-1-carboxylic acid · in 1 record
Experiment against prediction
- 4XAS chain B against the predicted model Q14416: TM-score 0.99, RMSD 0.71 Å
- 4XAS chain B against the predicted model Q14416: TM-score 0.99, RMSD 0.71 Å
- 4XAQ chain B against the predicted model Q14416: TM-score 0.99, RMSD 0.77 Å
- 4XAQ chain B against the predicted model Q14416: TM-score 0.99, RMSD 0.77 Å
- 5CNJ chain B against the predicted model Q14416: TM-score 0.99, RMSD 0.78 Å
- 4XAS chain A against the predicted model Q14416: TM-score 0.99, RMSD 0.83 Å
- 4XAS chain A against the predicted model Q14416: TM-score 0.99, RMSD 0.83 Å
- 4XAQ chain A against the predicted model Q14416: TM-score 0.99, RMSD 0.87 Å
- 4XAQ chain A against the predicted model Q14416: TM-score 0.99, RMSD 0.87 Å
- 5CNI chain A against the predicted model Q14416: TM-score 0.99, RMSD 0.83 Å
Elsewhere
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