Metabotropic glutamate receptor in complex with antagonist (1~{S}, 2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-BIS(FLUORANYL) PHENYL]SULFANYLMETHYL]-4-oxidanyl-BICYCLO[3.1.0]HEXANE-2,6- dicarboxylic acid

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 21% strand (DSSP).

Ligands and binding sites

• 6YS · (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid · ligand · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 6 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

• 5KZQ · Metabotropic Glutamate Receptor in complex with antagonist… · the same entry in another collection · chain A against A, TM-score 1.00
• Q14416 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 2 (Q14416) · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q14416
• Elsewhere: RCSB PDB 5KZQ · PDBe 5KZQ · UniProt Q14416