Cryo-EM structure of gi-bound metabotropic glutamate receptor MGLU2

Structure

electron microscopy · 7 distinct chains.

Ligands and binding sites

• 40F · (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid · ligand · 2 copies · chains R, S
• HZR · 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7E9G · Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu2 · the same entry in another collection · chain F against F, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.98
• Q14416 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 2 (Q14416) · a predicted model of the same protein · chain S against A, TM-score 0.84
• P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q14416
• Every structure of UniProt P63096
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Elsewhere: RCSB PDB 7E9G · PDBe 7E9G · UniProt Q14416 · UniProt P63096 · UniProt P62873 · UniProt P59768